New Horizons for Multiple Sclerosis Therapy: 2025 and Beyond.

The advances achieved against multiple sclerosis (MS) represent one of the great success stories of modern molecular medicine. The development of therapies with increasing selectivity and safety, guided by gains in understanding the fundamental immunology, neurobiology, genetics, and triggers of this disease, have broadened the traditional focus on treatment, adding realistic possibilities for prevention and repair. Here, we summarize recent advances that have together transformed the disease from the most common crippler of young adults in the western world to its place today as a condition in which most newly diagnosed patients can anticipate lives free from disability. ANN NEUROL 2025;98:317-328.