Di Nola F, Soranzo M L, Capra E, Eandi M, Salassa B, Arione R, Cimino T, Grosa M, Chiavarino M, Bramato C
Minerva Med. 1985 Oct 13;76(39):1795-801.
In vitro cefoperazone proved more active against the tested gram-negative bacteria than either piperacillin or mezlocillin. When administered in 1 g venous bolus the antibiotic achieved high plasmatic concentrations that were still adequate after 8 hours. 33.2% was excreted by the kidneys and a considerable amount by the biliary way. Cefoperazone produced a clinical cure in 35/36 patients (97.22%). A disulfiram-like effect was noted in 18.18%.
体外实验表明，头孢哌酮对测试的革兰氏阴性菌的活性比哌拉西林或美洛西林更强。静脉推注1克该抗生素后，其血浆浓度很高，8小时后仍保持在有效水平。33.2%经肾脏排泄，相当一部分经胆汁排泄。36例患者中有35例（97.22%）临床治愈。18.18%的患者出现了双硫仑样反应。
