Minerva Med. 1985 Oct 13;76(39):1803-11.
An Italian multi-centre trial of buflomedil in the clinical management of 814 cases of lower limb artery obstruction is reported. The incidence of risk factors in relation to age, sex and clinical stage is discussed. There were many patients under 55 with claudicatio intermittens. Smoking was the main risk factor, followed by hyperdyslipidaemia, in patients in the 7th decade of life. The incidence of diabetes was higher than that of other risk factors in women. Treatment with buflomedil for 3 months led to a significant improvement in signs and symptoms in all four clinical stages. In particular, walking range in the 2nd stage increased by 125.3% on an average (p less than 0.001), with a significant improvement after only 1 month. Improvement was dose-dependent in nearly all cases (94.9%).
本文报道了一项在意大利进行的多中心试验，该试验对814例下肢动脉阻塞患者使用丁咯地尔进行临床治疗。文中讨论了与年龄、性别及临床分期相关的危险因素的发生率。有许多55岁以下的间歇性跛行患者。吸烟是主要危险因素，其次是高脂血症，在70岁左右的患者中尤为如此。糖尿病在女性患者中的发生率高于其他危险因素。使用丁咯地尔治疗3个月后，所有四个临床分期的体征和症状均有显著改善。特别是，第二阶段的步行距离平均增加了125.3%（p<0.001），仅1个月后就有显著改善。几乎在所有病例（94.9%）中，改善都呈剂量依赖性。
