Synthesis of Oxa-spiro-bicyclo[2.1.1]hexane by Au/Sc Relay Catalysis.
作者信息
Zhu Yunjie, Hou Yangdong, Xu Zhenghu
机构信息
Key Lab for Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
出版信息
Org Lett. 2025 Jun 20;27(24):6362-6367. doi: 10.1021/acs.orglett.5c01542. Epub 2025 Jun 6.
PMID:40474774
Abstract
A new Au/Sc relay catalysis approach has been developed for the rapid construction of oxa-spiro-bicyclo[2.1.1]hexanes under mild conditions. This cascade reaction proceeds via a gold-catalyzed cycloisomerization followed by a Sc(OTf)-catalyzed [3+2] cycloaddition with bicyclo[1.1.0]butanes (BCBs) in less than 1 h.
摘要
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