里昂高血压品系新生大鼠的脑、脊髓和肾上腺儿茶酚胺浓度

Brain, spinal cord and adrenal catecholamine concentrations in neonate rats of the Lyon hypertensive strain.

作者信息

Denoroy L, Sautel M, Sacquet J, Vincent M, Sassard J

出版信息

Neurosci Lett. 1985 Jul 31;58(2):165-70. doi: 10.1016/0304-3940(85)90158-2.

Abstract

The catecholamine concentrations were determined in brain parts, spinal cord and adrenals of neonate hypertensive rats of the Lyon strain (LH), compared to normotensive (LN) and low-blood-pressure (LL) control rats. In adrenals of LH rats, noradrenaline and adrenaline concentrations are increased, and 3,4-dihydroxyphenylacetic acid (DOPAC) concentration decreased. At the central level, the DOPAC concentration and the ratio DOPAC/dopamine are decreased in the mesencephalon and the forebrain of LH rats. These results suggest that neonate LH rats exhibit a decreased activity in central dopaminergic neurons, and an enhanced maturation of the adrenals.

摘要

测定了里昂品系新生高血压大鼠（LH）脑区、脊髓和肾上腺中的儿茶酚胺浓度，并与正常血压（LN）和低血压（LL）对照大鼠进行比较。在LH大鼠的肾上腺中，去甲肾上腺素和肾上腺素浓度升高，而3,4-二羟基苯乙酸（DOPAC）浓度降低。在中枢水平，LH大鼠中脑和前脑的DOPAC浓度以及DOPAC/多巴胺比值降低。这些结果表明，新生LH大鼠中枢多巴胺能神经元的活性降低，肾上腺成熟增强。