Naeem Muhammad, Markus Marcello Ricardo Paulista, Bahls Martin, Mousa Mohammed, Dörr Marcus, Kühn Jens-Peter, Bülow Robin, Felix Stephan B, Targher Giovanni, Stubbe Beate, Ewert Ralf, Völzke Henry, Ittermann Till
Institute for Community Medicine, SHIP/Department of Clinical Epidemiology, Greifswald, Germany.
Department of Zoology, University of Malakand, Chakdara Dir (L), Pakistan.
Ups J Med Sci. 2025 May 16;130. doi: 10.48101/ujms.v130.11924. eCollection 2025.
The associations between physical fitness markers and liver volume in the general population are unclear. We investigated the associations of peak oxygen uptake (VO)and handgrip strength with liver volume in a general population sample.
Data were taken from 1,531 German adults (51.3% women), aged 20 to 88 years, from two cohorts of the population-based Study of Health in Pomerania (SHIP-START-2 and SHIP-TREND-0). We analysed cross-sectional associations of VO and handgrip strength with liver volume derived from magnetic resonance imaging (MRI) by using multivariable linear regression models. These models were adjusted for age, sex, body fat mass, pre-existing type 2 diabetes, daily alcohol consumption, smoking status, and use of hypoglycaemic or antihypertensive medications. We observed significant associations of lower VO and handgrip strength with a smaller liver volume in the whole population, as well as in both men and women. In the whole population, a 1 L/min lower VO was associated with a 0.15 cm (95% confidence interval [CI]: 0.11 to 0.19; < 0.0001) smaller liver volume for both sexes together. Similarly, a 1 kg lower handgrip strength was associated with a 7.05 cm (95% CI: 4.87 to 9.23; < 0.001) smaller liver volume in the whole population.
Our results derived from a large community-based sample showed that lower values of VO and handgrip strength were associated with a smaller liver volume. These results might explain the possible negative effects of sedentary lifestyle on liver volume - the sedentary liver.
普通人群中体能指标与肝脏体积之间的关联尚不清楚。我们在一个普通人群样本中研究了峰值摄氧量（VO）和握力与肝脏体积的关联。
数据取自德国波美拉尼亚健康研究（SHIP-START-2和SHIP-TREND-0）两个队列中的1531名20至88岁的成年人（51.3%为女性）。我们使用多变量线性回归模型分析了VO和握力与磁共振成像（MRI）得出的肝脏体积的横断面关联。这些模型针对年龄、性别、体脂量、已患2型糖尿病、每日饮酒量、吸烟状况以及使用降糖或降压药物进行了调整。我们在整个人群以及男性和女性中均观察到较低的VO和握力与较小的肝脏体积之间存在显著关联。在整个人群中，VO每降低1 L/min，两性的肝脏体积共减小0.15 cm（95%置信区间[CI]：0.11至0.19；P<0.0001）。同样，在整个人群中，握力每降低1 kg，肝脏体积减小7.05 cm（95%CI：4.87至9.23；P<0.001）。
我们基于大型社区样本得出的结果表明，较低的VO和握力值与较小的肝脏体积相关。这些结果可能解释了久坐不动的生活方式对肝脏体积——“久坐肝脏”的可能负面影响。
