链脲佐菌素诱导的糖尿病大鼠视网膜中，[2-3H]甘油在磷脂和中性甘油酯生物合成中的利用率降低。

Decreased utilization of [2-3H]glycerol in phospholipid and neutral glyceride biosynthesis in the retina of streptozotocin-diabetic rats.

作者信息

Bazan H E, Careaga M M, Bazan N G

出版信息

Neurochem Pathol. 1985 Summer;3(2):109-18. doi: 10.1007/BF02834284.

Abstract

The effect of streptozotocin (STZ)-induced diabetes on lipid uptake was studied in the rat retina. The intravitreal incorporation of [2-3H]glycerol was followed in retinal lipids from the first day of diabetes (acute state) up to 20 wk (chronic state). Total lipid incorporation decreased 50% 2 d after injection of STZ; the labeling remained lower than the control values throughout the 20 wk period studied. In the chronic state of diabetes, the time-course of the incorporation of [2-3H]glycerol during the first 2 h after its injection displayed a pattern of incorporation similar to that of the controls. The possibility that the decreased utilization of [2-3H]glycerol in the lipid pathway results from a competition between the injected [3H]glycerol and the glycolytic pathway during diabetes in rat retina in vivo is discussed.

摘要

研究了链脲佐菌素（STZ）诱导的糖尿病对大鼠视网膜脂质摄取的影响。从糖尿病第一天（急性期）到20周（慢性期），跟踪[2-³H]甘油在视网膜脂质中的玻璃体内掺入情况。注射STZ后2天，总脂质掺入量降低了50%；在整个研究的20周期间，标记物含量一直低于对照值。在糖尿病慢性期，注射[2-³H]甘油后最初2小时内其掺入的时间进程呈现出与对照相似的掺入模式。本文讨论了在大鼠视网膜体内糖尿病期间，脂质途径中[2-³H]甘油利用减少是否是由于注射的[³H]甘油与糖酵解途径之间竞争所致。