胶质母细胞瘤患者的神经认知功能与健康相关生活质量：一项前瞻性研究。
Neurocognitive function and health-related quality of life among glioblastoma patients: A prospective study.
作者信息
Baba Mohamed A, Kharbach Ahmed, Lmejjati Mohamed, Adali Nawal
机构信息
Department of Public Health, Faculty of Medicine and Pharmacy of Agadir, Ibn Zohr University, Agadir, Morocco.
Laboratory of Cell Biology and Molecular Genetics, Department of Biology, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco.
出版信息
J Public Health Afr. 2025 Jan 10;16(1):660. doi: 10.4102/jphia.v16i1.660. eCollection 2025.
BACKGROUND
Glioblastomas are aggressive brain tumours that significantly impact patients' functional and psychological well-being, making the evaluation of health-related quality of life (HRQoL) essential.
AIM
This study aims to assess the quality of life (QoL) and neurocognitive status of glioblastoma patients in Morocco.
SETTING
Patients were recruited from two renowned oncology centres in Morocco.
METHODS
Patients receiving care at two renowned oncology centres were enrolled between April 2021 and January 2024. The QLQ-C30 and QLQ-BN20 scales were used to assess QoL, while neurocognitive function was evaluated using the Mini-Mental State Examination (MMSE) test. Data normality were checked using the Shapiro-Wilk test, and non-parametric methods were used to compare scores. Variables such as age, tumour laterality, residence, and educational status were examined for their association with overall QoL. Both univariate linear regression and multivariate regression analyses were conducted. Statistical analyses were performed using the JAMOVI software.
RESULTS
The study enrolled 106 patients, with a median age of 56.7 years. Among them, 66% were male, while 34% were female. Multiple linear regression showed that age (B: -15.46; 95% CI: -24.15 to -6.77; < 0.001), education level (B: -9.36; 95% CI: 0.84 to 17.88; = 0.032), distance from hospital (B: -9.85; 95% CI: -18.34 to -1.36; = 0.023), and tumour laterality (B= -12.36; 95% CI: -20.65 to -4.06; = 0.004) were significantly associated with overall QoL at 3 months follow-up.
CONCLUSION
The results indicate a decline in HRQoL during follow-up among glioblastoma patients. Advancing age, tumour location on the left side, education level, and proximity to the hospital significantly influence the overall QoL.
CONTRIBUTION
This study highlights the critical factors impacting HRQoL in glioblastoma patients in Morocco, providing insights for improving patient care.
背景
胶质母细胞瘤是侵袭性脑肿瘤，会对患者的功能和心理健康产生重大影响，因此评估健康相关生活质量（HRQoL）至关重要。
目的
本研究旨在评估摩洛哥胶质母细胞瘤患者的生活质量（QoL）和神经认知状态。
地点
患者来自摩洛哥的两个著名肿瘤中心。
方法
2021年4月至2024年1月期间，招募了在两个著名肿瘤中心接受治疗的患者。使用QLQ-C30和QLQ-BN20量表评估生活质量，同时使用简易精神状态检查表（MMSE）测试评估神经认知功能。使用夏皮罗-威尔克检验检查数据正态性，并使用非参数方法比较得分。检查年龄、肿瘤侧别、居住地和教育程度等变量与总体生活质量的关联。进行了单变量线性回归和多变量回归分析。使用JAMOVI软件进行统计分析。
结果
该研究共纳入106例患者，中位年龄为56.7岁。其中，66%为男性，34%为女性。多元线性回归显示，年龄（B：-15.46；95%置信区间：-24.15至-6.77；<0.001）、教育水平（B：-9.36；95%置信区间：0.84至17.88；=0.032）、与医院的距离（B：-9.85；95%置信区间：-18.34至-1.36；=0.023）和肿瘤侧别（B=-12.36；95%置信区间：-20.65至-4.06；=0.004）在3个月随访时与总体生活质量显著相关。
结论
结果表明，胶质母细胞瘤患者随访期间HRQoL下降。年龄增长、肿瘤位于左侧、教育水平和与医院的距离显著影响总体生活质量。
贡献
本研究突出了影响摩洛哥胶质母细胞瘤患者HRQoL的关键因素，为改善患者护理提供了见解。
Zotero 插件