Karadoğan Dilek, Telatar Tahsin Gökhan, Kaya İlknur, Atlı Siahmet, Kabil Neslihan Köse, Marım Feride, Şenel Merve Yumrukuz, Yüksel Aycan, Yalçın Burcu, Gültekin Ökkeş, Erçelik Merve, Akgün Metin
Department of Chest Diseases, Recep Tayyip Erdoğan University, School of Medicine, Rize, Türkiye.
Department of Public Health, Recep Tayyip Erdoğan University, School of Medicine, Rize, Türkiye.
Tob Induc Dis. 2025 Jun 5;23. doi: 10.18332/tid/204254. eCollection 2025.
A significant proportion of patients with chronic airway diseases continue to smoke even after the diagnosis. In addition, smoking cessation support continues to be a neglected issue in real-life settings by physicians for that patient group. Therefore, in our search for a solution to this issue, we conducted our study to evaluate the effect of arranging immediate appointments to smoking cessation outpatient clinics on smoking cessation success in patients with chronic airway disease.
This multicenter, randomized, parallel-arm prospective study (NCT05764343) was conducted in pulmonary outpatient clinics between November 2022 and June 2023. Current smoker patients aged ≥18 years diagnosed with COPD, asthma, or bronchiectasis for at least 6 months were included and sequentially randomized in a 1:1 ratio. Both arms received brief smoking cessation interventions, and the intervention arm had immediate access to a smoking cessation clinic appointment. In contrast, the control arm received a standard quitline appointment for routine service. The primary endpoint was the self-reported smoking cessation rate at 3 months, analyzed using an intentionto-treat approach.
The study comprised 198 patients in the immediate appointment arm and 199 in the usual care arm. The quit rate was significantly higher in the immediate appointment arm (26.7%) than in the usual care arm (16.5%, p=0.014). Access to smoking cessation medication was 69.3% in the intervention group against 22.0% in the control group (p<0.001). Multivariable analysis identified access to smoking cessation medication as the sole significant predictor of cessation success at 3 months (adjusted odds ratio, AOR=5.64; 95% CI: 2.89-11.03).
Our study revealed that access to evidence-based smoking cessation support is positively associated with successful quitting. Compared to the usual care arm, the immediately appointment-scheduled arm has a higher access rate of cessation support. Therefore, smoking cessation support, including pharmacotherapy, should be part of routine care for patients with chronic airway diseases.
The study is registered on the official website of ClinicalTrials.gov Identifier: ID NCT05764343.
相当一部分慢性气道疾病患者即使在确诊后仍继续吸烟。此外，在现实生活中，戒烟支持仍然是医生对该患者群体忽视的一个问题。因此，为了寻找解决这个问题的方法，我们开展了这项研究，以评估安排戒烟门诊即时预约对慢性气道疾病患者戒烟成功率的影响。
这项多中心、随机、平行组前瞻性研究（NCT05764343）于2022年11月至2023年6月在肺部门诊进行。纳入年龄≥18岁、诊断为慢性阻塞性肺疾病（COPD）、哮喘或支气管扩张至少6个月的现吸烟者，并按1:1的比例依次随机分组。两组均接受简短的戒烟干预，干预组可即时预约戒烟门诊。相比之下，对照组接受常规服务的标准戒烟热线预约。主要终点是3个月时自我报告的戒烟率，采用意向性分析方法进行分析。
即时预约组有198名患者，常规护理组有199名患者。即时预约组的戒烟率（26.7%）显著高于常规护理组（16.5%，p=0.014）。干预组获得戒烟药物的比例为69.3%，而对照组为22.0%（p<0.001）。多变量分析确定获得戒烟药物是3个月时戒烟成功的唯一显著预测因素（调整优势比，AOR=5.64；95%置信区间：2.89-11.03）。
我们的研究表明，获得循证戒烟支持与成功戒烟呈正相关。与常规护理组相比，即时预约组获得戒烟支持的比例更高。因此，包括药物治疗在内的戒烟支持应成为慢性气道疾病患者常规护理的一部分。
该研究已在ClinicalTrials.gov官方网站注册，标识符：ID NCT05764343。
