Rahimi-Eichi Habiballah, Baker Justin T, Fjell Anders M, Buckner Randy L
Department of Psychology, Center for Brain Science, Harvard University, Cambridge, MA 02138.
Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA 02478.
bioRxiv. 2025 May 20:2025.05.15.654262. doi: 10.1101/2025.05.15.654262.
Robust age- and sex-related differences in sleep were identified (n=38,546) and replicated (n=38,547) from week-long passive actigraphy data in UK Biobank participants ages 44-82. Sleep patterns reflected reliable non-linear interactions between age and sex. Younger women slept about 17 min more than their male counterparts, though this difference diminished with age, with both sexes reducing total sleep duration in later life. Middle-aged individuals exhibited shorter sleep durations during the week, with weekend sleep increasing by as much as 50 min. Participants in their seventh and eighth decades showed more consistent sleep patterns throughout the week. Sleep patterns also suggest maintenance of total sleep duration: individuals reporting waking too early maintain sleep duration by going to sleep earlier, while individuals reporting sleeping too much fall asleep later but also wake later, again maintaining sleep duration. Self-reported depression and anhedonia were associated with reduced total sleep duration across multiple age groups and both sexes. These collective results indicate that the timing, consistency, and overall amount of sleep differs by age and is affected by individual factors.
在英国生物银行44至82岁参与者中，从为期一周的被动式活动记录仪数据中识别出了与年龄和性别相关的显著睡眠差异（n=38,546），并进行了重复验证（n=38,547）。睡眠模式反映了年龄和性别之间可靠的非线性相互作用。年轻女性比同龄男性睡眠时间约多17分钟，不过这种差异会随着年龄增长而减小，两性在晚年的总睡眠时间都会减少。中年人在工作日的睡眠时间较短，周末睡眠时间增加多达50分钟。七十多岁和八十多岁的参与者在一周内的睡眠模式更为一致。睡眠模式还表明总睡眠时间保持稳定：报告过早醒来的人通过更早入睡来维持睡眠时间，而报告睡眠时间过长的人入睡较晚但醒来也较晚，同样维持了睡眠时间。自我报告的抑郁和快感缺乏与多个年龄组和两性的总睡眠时间减少有关。这些综合结果表明，睡眠的时间、一致性和总量因年龄而异，并受个体因素影响。
