Andreatidis Brielle, Weber Nicholas, Craven Ann-Maree, Duke Madeline, Callaway Leonie, Eccles-Smith Jade
Department of Obstetrics and Gynaecology, The Royal Brisbane and Women's Hospital, Herston, Australia.
Cancer Care Services, The Royal Brisbane and Women's Hospital, Herston, Australia.
Obstet Med. 2025 Jun 3:1753495X251338163. doi: 10.1177/1753495X251338163.
Thrombotic thrombocytopenic purpura (TTP) is a serious but rare cause of thrombocytopenia in pregnancy which poses a significant morbidity and mortality burden to the maternofetal dyad. Diagnosing TTP in pregnancy is challenging due to its non-specific clinical presentation, and the potential for similar or concomitant presentation with other thrombotic microangiopathies. We present an atypical case of TTP diagnosed in an asymptomatic 28-year-old female, at 35 weeks' gestation. TTP must be considered a differential for thrombocytopenia, especially in the context of autoimmune disease and even in the absence of typical signs or symptoms. Increasingly available diagnostic tools may help redefine our understanding of TTP presentations in pregnancy.
血栓性血小板减少性紫癜（TTP）是妊娠期血小板减少的一个严重但罕见的病因，对母婴双方都构成了重大的发病和死亡负担。由于其临床表现不具特异性，且可能与其他血栓性微血管病表现相似或同时出现，因此在妊娠期诊断TTP具有挑战性。我们报告一例非典型TTP病例，该病例为一名28岁无症状女性，孕35周时确诊。TTP必须被视为血小板减少的鉴别诊断疾病，尤其是在自身免疫性疾病的背景下，甚至在没有典型体征或症状的情况下。越来越多可用的诊断工具可能有助于重新定义我们对妊娠期TTP表现的认识。
