Zhao Tingting, Ma Yan, Zheng Zhimin, Zhang Panpan, Sun Hao
Dalian Women and Children's Medical Center (Group), Dalian, Liaoning, China.
Graduate School of Dalian Medical University, Dalian, Liaoning, China.
Front Endocrinol (Lausanne). 2025 May 22;16:1553008. doi: 10.3389/fendo.2025.1553008. eCollection 2025.
Growth hormone deficiency (GHD) is a rare endocrine disorder characterized by reduced or insufficient secretion of growth hormone (GH). GHD manifests with a heterogenous spectrum of symptoms mainly affecting musculoskeletal and endocrine system, with an increased predisposition to psychosocial disorders and ultimately reduced quality of life.
We searched the main databases for studies describing the metabolic effects of growth hormone and its deficiency. All full-text articles and major reviews were manually searched for additional studies.
Metabolic derangements of GHD are reported in carbohydrate (insulin resistance, diabetes mellitus), lipid (hypercholesterolemia, hypertriglyceridemia), and protein (decreased lean body mass) metabolism. Currently, recombinant growth hormone (rhGH) replacement therapy is the primary standard of care for the treatment of GHD. Understanding the impact of GH, including the effect of GHD and rhGH therapy, on metabolism would be a critical step in development of effective treatment and selecting the best management strategies.
This article reviews research progress and aims to offer new perspectives on the metabolic state of patients suffering from GHD and to compile data about the impact of rhGH therapy on metabolic pathways.
生长激素缺乏症（GHD）是一种罕见的内分泌疾病，其特征是生长激素（GH）分泌减少或不足。GHD表现出一系列异质性症状，主要影响肌肉骨骼和内分泌系统，易患心理社会障碍，最终导致生活质量下降。
我们在主要数据库中搜索描述生长激素及其缺乏的代谢影响的研究。对所有全文文章和主要综述进行人工搜索以寻找其他研究。
据报道，GHD在碳水化合物（胰岛素抵抗、糖尿病）、脂质（高胆固醇血症、高甘油三酯血症）和蛋白质（瘦体重减少）代谢方面存在代谢紊乱。目前，重组生长激素（rhGH）替代疗法是治疗GHD的主要标准治疗方法。了解GH对代谢的影响，包括GHD和rhGH治疗的影响，将是开发有效治疗方法和选择最佳管理策略的关键一步。
本文回顾了研究进展，旨在为GHD患者的代谢状态提供新的视角，并汇总有关rhGH治疗对代谢途径影响的数据。
