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在GeneXpert仪器系统上进行的Xpert MTB/RIF检测中，验证阳性结果的循环阈值的重要性。

Importance of Verifying the Cycle Threshold for Positive Results From Xpert MTB/RIF Assay, Performed on the GeneXpert Instrument Systems.

作者信息

Gitman Melissa R, Nowak Michael D

机构信息

Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

出版信息

Open Forum Infect Dis. 2025 May 15;12(6):ofaf297. doi: 10.1093/ofid/ofaf297. eCollection 2025 Jun.

DOI:10.1093/ofid/ofaf297
PMID:40476035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12138502/
Abstract

Providers need to be aware of the potential causes of false positive Xpert TB test results, this letter provides a practical approach to confirm and differentiate between a true positive by reviewing that all probes are positive and the Ct values have reached a certain threshold.

摘要

医疗服务提供者需要了解Xpert结核检测结果假阳性的潜在原因，本信函提供了一种实用方法，通过检查所有探针均为阳性且Ct值达到一定阈值来确认并区分真阳性。

相似文献

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Importance of Verifying the Cycle Threshold for Positive Results From Xpert MTB/RIF Assay, Performed on the GeneXpert Instrument Systems.在GeneXpert仪器系统上进行的Xpert MTB/RIF检测中，验证阳性结果的循环阈值的重要性。
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本文引用的文献

1
Limitations of the MTB/RIF Assay: An Xpert Review of 4 Clinical Cases.MTB/RIF检测的局限性：4例临床病例的Xpert回顾
Open Forum Infect Dis. 2025 Mar 5;12(4):ofaf132. doi: 10.1093/ofid/ofaf132. eCollection 2025 Apr.
2
Clinical Validation of the Xpert MTB/RIF Test for Identification of the Mycobacterium tuberculosis Complex in Acid-Fast Bacillus Smear-Positive MGIT Broth Cultures.Xpert MTB/RIF 检测对酸性快速分枝杆菌涂片阳性 MGIT 肉汤培养物中结核分枝杆菌复合群的鉴定的临床验证。
J Clin Microbiol. 2022 Feb 16;60(2):e0216421. doi: 10.1128/JCM.02164-21. Epub 2022 Jan 5.
3
Low Cycle Threshold Value in Xpert MTB/RIF Assay May Herald False Detection of Tuberculosis and Rifampicin Resistance: A Study of Two Cases.Xpert MTB/RIF检测中低循环阈值可能预示着结核病和利福平耐药性的假检测：两例病例研究
Open Forum Infect Dis. 2021 Jan 21;8(2):ofab034. doi: 10.1093/ofid/ofab034. eCollection 2021 Feb.
4
Misdiagnosis of tuberculosis associated with some species of nontuberculous mycobacteria by GeneXpert MTB/RIF assay.GeneXpert MTB/RIF assay 对某些非结核分枝杆菌导致的结核误诊。
Infection. 2017 Oct;45(5):677-681. doi: 10.1007/s15010-017-1044-x. Epub 2017 Jul 13.