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Structural insights into MPXV P1 protein and its orthologs reveal conformational dynamics and a conserved antiviral pocket.

作者信息

Ni Xincheng, Wang Yuanda, Fan Xinyu, Yu Jiao, Lei Jian

机构信息

National Clinical Research Center for Geriatrics, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

出版信息

Emerg Microbes Infect. 2025 Dec;14(1):2515408. doi: 10.1080/22221751.2025.2515408. Epub 2025 Jun 19.

DOI:10.1080/22221751.2025.2515408
PMID:40476512
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12180345/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f43/12180345/989ed478acea/TEMI_A_2515408_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f43/12180345/989ed478acea/TEMI_A_2515408_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f43/12180345/989ed478acea/TEMI_A_2515408_F0001_OC.jpg

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本文引用的文献

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Hopes dashed for drug aimed at monkeypox virus spreading in Africa.针对在非洲传播的猴痘病毒的药物研发希望破灭。
Nature. 2024 Aug;632(8027):965. doi: 10.1038/d41586-024-02694-x.
2
Simultaneous Improvement in the Thermostability and Catalytic Activity of Epoxidase Lsd18 for the Synthesis of Lasalocid A.同时提高脂加氧酶 Lsd18 的热稳定性和催化活性用于合成莱萨洛昔。
Int J Mol Sci. 2023 Nov 27;24(23):16795. doi: 10.3390/ijms242316795.
3
An Overview of Antivirals against Monkeypox Virus and Other Orthopoxviruses.抗猴痘病毒及其他正痘病毒的抗病毒药物概述
J Med Chem. 2023 Apr 13;66(7):4468-4490. doi: 10.1021/acs.jmedchem.3c00069. Epub 2023 Mar 24.
4
Inhibition of apoptosis and NF-κB activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence.牛痘蛋白 N1 通过不同的结合表面抑制细胞凋亡和 NF-κB 激活，对病毒毒力有不同的贡献。
PLoS Pathog. 2011 Dec;7(12):e1002430. doi: 10.1371/journal.ppat.1002430. Epub 2011 Dec 15.
5
Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention.牛痘病毒毒力因子 N1L 是抗病毒治疗干预的一个新的有希望的靶点。
J Med Chem. 2010 May 27;53(10):3899-906. doi: 10.1021/jm901446n.
6
A poxvirus Bcl-2-like gene family involved in regulation of host immune response: sequence similarity and evolutionary history.痘病毒 Bcl-2 样基因家族参与宿主免疫反应的调控：序列相似性和进化历史。
Virol J. 2010 Mar 15;7:59. doi: 10.1186/1743-422X-7-59.
7
Vaccinia virus lacking the Bcl-2-like protein N1 induces a stronger natural killer cell response to infection.缺乏Bcl-2样蛋白N1的痘苗病毒对感染诱导出更强的自然杀伤细胞反应。
J Gen Virol. 2008 Nov;89(Pt 11):2877-2881. doi: 10.1099/vir.0.2008/004119-0.
8
Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein.痘苗病毒毒力因子N1的功能和结构研究揭示了一种类Bcl-2抗凋亡蛋白。
J Gen Virol. 2007 Jun;88(Pt 6):1656-1666. doi: 10.1099/vir.0.82772-0.
9
Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein.痘苗病毒N1L蛋白类似于B细胞淋巴瘤-2（Bcl-2）家族蛋白。
Protein Sci. 2007 Jan;16(1):118-24. doi: 10.1110/ps.062454707. Epub 2006 Nov 22.
10
Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors.痘病毒蛋白N1L靶向I-κB激酶复合物，抑制肿瘤坏死因子超家族受体向NF-κB的信号传导，并通过Toll样受体抑制NF-κB和IRF3信号传导。
J Biol Chem. 2004 Aug 27;279(35):36570-8. doi: 10.1074/jbc.M400567200. Epub 2004 Jun 23.