Yang Mengfan, Chen Yumiao, Liu Yefeng, Yang Jianhua, Lv Sha, Liu Shichun, Dong Yaoxi, Yang Qiao, Li Keyi, Song Shengfang, Li Hua
Department of Ophthalmology, Yongchuan Hospital, Chongqing Medical University, Chongqing, China.
Ophthalmic Physiol Opt. 2025 Sep;45(6):1447-1455. doi: 10.1111/opo.13532. Epub 2025 Jun 6.
To investigate rapid changes in axial length (AL) and regional changes in choroidal thickness (ChT) and the choroidal vessel index (CVI) in myopic children with myopia caused by optical defocus.
Sixty-two eyes of 31 children wearing Diverse Segments Defocus Optimization (DSDO) spectacle lenses and 58 eyes of 29 children wearing single-vision spectacle lenses (SVL) were included. All participants were fully corrected and evaluated before and immediately after 30 min of reading. ChT and CVI were measured using swept-source optical coherence tomography in different regions, including the central, inner and outer ring areas and the superior, inferior, nasal and temporal regions. AL was also measured.
At baseline, ChT was significantly lower in the nasal quadrant than in other quadrants (all p < 0.001) and the CVI was significantly higher in the nasal quadrant than in the superior and temporal quadrants (all p < 0.01). After 30 min of reading, AL was significantly reduced in the DSDO group and increased in the SVL group. In the DSDO group, the ChT increased significantly in all areas, with the greatest increase observed in the inner ring area. In the SVL group, the ChT decreased in all areas, with the smallest decrease occurring in the inner ring area. CVI did not change significantly after reading in either group.
In the early stage of lens wear, SVL induced a rapid increase in AL and decreased ChT in different areas, while DSDO induced rapid AL shortening and increased ChT in varying regions. ChT differed more in the inner than in the outer ring regions, while the superior region showed the most significant change in ChT. These findings provide new perspectives for the optimal design of optical defocus lenses.
研究因光学离焦导致近视的儿童的眼轴长度（AL）快速变化、脉络膜厚度（ChT）区域变化以及脉络膜血管指数（CVI）。
纳入31名佩戴多样段离焦优化（DSDO）眼镜片的儿童的62只眼和29名佩戴单焦点眼镜片（SVL）的儿童的58只眼。所有参与者在阅读30分钟之前和之后立即进行了全矫正和评估。使用扫频光学相干断层扫描在不同区域测量ChT和CVI，包括中央、内环和外环区域以及上、下、鼻和颞侧区域。还测量了AL。
在基线时，鼻侧象限的ChT显著低于其他象限（所有p<0.001），鼻侧象限的CVI显著高于上象限和颞侧象限（所有p<0.01）。阅读30分钟后，DSDO组的AL显著缩短，SVL组的AL增加。在DSDO组中，所有区域的ChT均显著增加，在内环区域观察到最大增加。在SVL组中，所有区域的ChT均下降，在内环区域下降最小。两组阅读后CVI均无显著变化。
在佩戴镜片的早期阶段，SVL导致AL快速增加且不同区域的ChT降低，而DSDO导致AL快速缩短且不同区域的ChT增加。ChT在内环区域比外环区域差异更大，而上区域ChT变化最为显著。这些发现为光学离焦镜片的优化设计提供了新的视角。
