Del Toro-Colín Miguel A, Tena-Suck Martha, Santiago-Balmaseda Alberto, Salinas-Lara Citlalteptl, Velázquez-Garcia Germán, de Lourdes Aguilar-Gómez Maria, León-Marroquín Elsa Yazmín, Sánchez-Garibay Carlos, Ortíz-Plata Alma, Carrillo-Meza Roger, Gelista-Herrera Noemi, Hernández-Roque Lesly, Soto-Rojas Luis O
Laboratorio de Patogénesis Molecular, Laboratorio 4, Edificio A4, Facultad de Estudios Superiores Iztacala, Carrera Médico Cirujano, Universidad Nacional Autónoma de México, 54090, Tlalnepantla, Edomex, Mexico.
Red MEDICI, Facultad de Estudios Superiores Iztacala, Carrera Médico Cirujano, Universidad Nacional Autónoma de México, 54090, Tlalnepantla, Edomex, Mexico.
Brain Tumor Pathol. 2025 Jun 6. doi: 10.1007/s10014-025-00504-4.
The coexistence of three lesions in the sellar region is exceedingly rare. Only two cases with three histopathologically distinct lesions have been reported. However, here, we present a unique case of a 54-year-old female with pituitary adenoma (PA), xanthogranulomatous hypophysitis (XGH), and a Rathke cleft cyst (RCC). Clinically, the patient manifested symptoms of mass compression, such as moderate-intensity headaches and progressive visual acuity decrease. Relevant endocrinological evaluation revealed elevated free thyroxine levels without clinical manifestations. MRI revealed a suprasellar mass compatible with a macroadenoma. The patient underwent transsphenoidal endoscopic resection, resulting in a non-functional macroadenoma with associated XGH due to the rupture of RCC. Furthermore, in this article, we analyze the possible mechanisms involved in the pathogenesis of these lesions, emphasizing the type of spectrum to which they belong and the manifestations present.
蝶鞍区三种病变并存极为罕见。仅报道过两例具有三种组织病理学不同病变的病例。然而，在此我们呈现了一例独特的54岁女性病例，其患有垂体腺瘤（PA）、黄色肉芽肿性垂体炎（XGH）和拉克氏囊肿（RCC）。临床上，患者表现出肿块压迫症状，如中度头痛和视力进行性下降。相关内分泌评估显示游离甲状腺素水平升高但无临床表现。磁共振成像（MRI）显示鞍上肿块符合大腺瘤表现。患者接受了经蝶窦内镜切除术，结果发现是一个无功能大腺瘤，伴有因RCC破裂导致的XGH。此外，在本文中，我们分析了这些病变发病机制中可能涉及的机制，强调了它们所属的谱系类型及所呈现的表现。
