Hennessy Declan Thomas, Miller Kyle J, Khan Nazib, Edo Sergio Marin, Bell Leo, Areerob Pinyadapat, Brown Stephen, Wallen Matthew
Institute of Health and Wellbeing, Federation University Australia, Ballarat, VIC, Australia.
School of Exercise and Nutrition Sciences, Faculty of Health, Deakin University, Melbourne Burwood Campus, Burwood, VIC, 3125, Australia.
Support Care Cancer. 2025 Jun 6;33(7):551. doi: 10.1007/s00520-025-09610-7.
Improving cardiorespiratory fitness (CRF) before and after colorectal cancer surgery may improve postoperative outcomes. This systematic review and meta-analysis evaluated the effects of perioperative exercise therapy (aerobic, resistance, mind-body, flexibility, or mixed exercise (combined aerobic and resistance)) on CRF, the ventilatory anaerobic threshold (VAT), postoperative complications, and adverse events for patients diagnosed with colorectal cancer undergoing surgery.
Eligible published randomised controlled trials (RCTs) were identified from an electronic database search (inception-31 May 2020 and updated 16 April 2024). Databases included PubMed, CINAHL, SPORTDiscus, Cochrane Library (CENTRAL), and Web of Science. Pooled standardised mean differences (SMD) with 95% confidence intervals (CI) were compared, and heterogeneity was assessed using Cochran's Q and I statistics.
Twenty-five eligible trials (1385 participants) were included in the meta-analysis. Perioperative exercise demonstrated significant improvements in CRF (SMD = 0.28, 95% CI = 0.17, 0.38; p < 0.05) and the VAT (SMD = 0.43, 95% CI = 0.23, 0.63; p < 0.05) when compared to usual care. No noticeable differences in postoperative complications or adverse events between the groups were found.
Perioperative exercise delivered before and after colorectal cancer surgery significantly improves CRF and the VAT.
提高结直肠癌手术前后的心肺适能（CRF）可能会改善术后结局。本系统评价和荟萃分析评估了围手术期运动疗法（有氧运动、抗阻运动、身心运动、柔韧性运动或混合运动（有氧运动和抗阻运动相结合））对接受手术的结直肠癌患者的CRF、通气无氧阈（VAT）、术后并发症和不良事件的影响。
通过电子数据库检索（起始时间为2020年5月31日，更新于2024年4月16日）确定符合条件的已发表随机对照试验（RCT）。数据库包括PubMed、CINAHL、SPORTDiscus、Cochrane图书馆（CENTRAL）和科学网。比较合并的标准化均数差（SMD）及其95%置信区间（CI），并使用Cochran's Q和I统计量评估异质性。
荟萃分析纳入了25项符合条件的试验（1385名参与者）。与常规护理相比，围手术期运动在CRF（SMD = 0.28，95%CI = 0.17，0.38；p < 0.05）和VAT（SMD = 0.43，95%CI = 0.23，0.63；p < 0.05）方面有显著改善。两组之间在术后并发症或不良事件方面未发现明显差异。
结直肠癌手术前后进行围手术期运动可显著改善CRF和VAT。
