Joshi Shubhi, Maan Mayank, Barman Panchali, Sharely Ikshika, Verma Kunal, Preet Simran, Saini Avneet
University School of Allied Health Sciences, Rayat Bahra University, Mohali, Punjab 140103, India.
Department of Biophysics, Panjab University, Chandigarh, UT 160014, India.
Adv Colloid Interface Sci. 2025 May 31;343:103563. doi: 10.1016/j.cis.2025.103563.
Healing wounds is no longer a passive process but a dynamic interplay between advanced materials, therapeutic agents and innovative technologies. Chronic wounds, aggravated by factors like diabetes, aging and multidrug-resistant infections, demand solutions beyond traditional dressings. Advanced wound care has evolved into an active therapeutic strategy, leveraging biomaterials that mimic the extracellular matrix, foster tissue regeneration and combat infections. Recent advances in fabrication techniques, such as three-dimensional bioprinting, electrospinning and microfluidic templating, have enabled precise customization of wound dressings tailored to complex clinical challenges. The integration of bioactive molecules and growth factors, further enhances the efficacy of these dressings. Emerging trends like bioengineered hydrogels and real-time monitoring systems have the potential to transform wound care into an intelligent, adaptive process that responds to patient-specific needs. By addressing the current challenges and exploring emerging biomaterials, a future with personalized scar-free wound healing technologies may be achieved in the future. The current article begins by providing an overview of skin, wounds and the factors responsible for delaying wound healing. With this background, the traditional and advanced biomaterial based wound care strategies have been discussed extensively. The main focus is to present a comprehensive account on the integrated approaches in advance wound care management, combining breakthroughs in material science, biotechnology and clinical innovations to revolutionize the field of wound healing. This review promises a one-stop exhaustive report that shall be the torchbearer for future research endeavours in the field of wound care and management.
伤口愈合不再是一个被动过程,而是先进材料、治疗剂和创新技术之间的动态相互作用。由糖尿病、衰老和多重耐药感染等因素加剧的慢性伤口,需要超越传统敷料的解决方案。先进的伤口护理已发展成为一种积极的治疗策略,利用模仿细胞外基质、促进组织再生和对抗感染的生物材料。制造技术的最新进展,如三维生物打印、静电纺丝和微流控模板技术,能够精确定制针对复杂临床挑战的伤口敷料。生物活性分子和生长因子的整合进一步提高了这些敷料的功效。生物工程水凝胶和实时监测系统等新兴趋势有可能将伤口护理转变为一个智能、自适应的过程,以满足患者的特定需求。通过应对当前的挑战并探索新兴生物材料,未来可能实现个性化无瘢痕伤口愈合技术的未来。本文首先概述了皮肤、伤口以及导致伤口愈合延迟的因素。在此背景下,广泛讨论了基于传统和先进生物材料的伤口护理策略。主要重点是全面阐述先进伤口护理管理中的综合方法,结合材料科学、生物技术和临床创新的突破,彻底改变伤口愈合领域。这篇综述有望成为一份一站式详尽报告,为伤口护理和管理领域未来的研究努力指明方向。