Wu M, Harding R K, Hugenholtz H, Kucharczyk J
Peptides. 1985;6 Suppl 1:173-5. doi: 10.1016/0196-9781(85)90028-2.
Short-latency emetic responses were induced in dogs by injecting angiotensin II (AII), arginine vasopressin (AVP), and neurotensin (NTN) into cerebroventricular (ICV) and cisternal (ICT) sites also responsive to the emetic effects of apomorphine (APO). Angiotensin III, bradykinin, bombesin, oxytocin, adrenocorticotropic hormone, substance P, gastrin-related peptide and cholecystokinin were ineffective. The results suggest a possible dopaminergic mediation of peptide-induced emesis by receptors in the area postrema (AP).
通过将血管紧张素II（AII）、精氨酸加压素（AVP）和神经降压素（NTN）注射到对阿扑吗啡（APO）催吐作用也有反应的脑室（ICV）和脑池（ICT）部位，可诱导犬产生短潜伏期催吐反应。血管紧张素III、缓激肽、蛙皮素、催产素、促肾上腺皮质激素、P物质、胃泌素相关肽和胆囊收缩素均无效。结果提示，肽诱导的呕吐可能由最后区（AP）的受体通过多巴胺能介导。
