Guo Yi, Guan Xin, You Yutong, Jia Chengyong, Lin Yuhui, Yin Zhen, Yin Yu, Zhong Guorong, Wen Yuying, Li Wenhui, Zhao Hui, Chen Shengli, Wang Xi, Li Xinlian, Mu Xuanwen, Long Pinpin, Wang Hao, Zhang Xiaomin, He Meian, Yuan Yu, Jing Tao, Guo Huan, Wu Tangchun
Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Environ Int. 2025 Jul;201:109571. doi: 10.1016/j.envint.2025.109571. Epub 2025 May 30.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease globally. However, its environmental chemical contributors remain unclear.
To estimate the association between organochlorine pesticides (OCPs) and incident MASLD among Chinese population.
We conducted a longitudinal study involving 1199 participants based on Dongfeng-Tongji cohort. Serum concentrations of 19 OCPs at baseline were assessed and MASLD was defined using the updated guidelines. We fitted multivariate logistic regression models to estimate the association between OCPs and MASLD. Restricted cubic spline was utilized to illustrate their potential non-linear dose-response relationships. We additionally investigated the interactive and joint effects of β-HCH and ΣDDTs, and performed stratified analyses to explore potential effect modifications.
Compared to the lowest quartile, participants in the highest quartile of serum β-HCH and ΣDDTs had 2.48- and 1.95-fold higher odds of MASLD, respectively [Model 3: OR (95% CI) = 2.48 (1.37, 4.56) for β-HCH and 1.95 (1.20, 3.21) for ΣDDTs]. While β-HCH showed a linear association with incident MASLD, a non-linear relationship was noted for ΣDDTs (P for non-linear = 0.044). Stratified analysis suggested that the association could not be significantly modified by demographic or lifestyle factors. Meanwhile, individuals with both high β-HCH and ΣDDTs had the highest odds of MASLD compared to those with both low levels [OR (95% CI) = 2.90 (1.66, 5.18)].
This longitudinal study revealed that higher levels of β-HCH and ΣDDTs were associated with increased odds of MASLD, with a positive joint effect. More attention is needed on the harmful effects of OCP co-exposure and acceleration of OCP removal.
代谢功能障碍相关脂肪性肝病（MASLD）是全球最普遍的慢性肝病。然而，其环境化学促成因素仍不清楚。
评估中国人群中有机氯农药（OCPs）与新发MASLD之间的关联。
我们基于东风-同济队列对1199名参与者进行了一项纵向研究。评估了基线时19种OCPs的血清浓度，并使用更新后的指南定义MASLD。我们拟合多变量逻辑回归模型以评估OCPs与MASLD之间的关联。采用受限立方样条来描述它们潜在的非线性剂量反应关系。我们还研究了β-六氯环己烷和总滴滴涕的交互作用和联合效应，并进行分层分析以探索潜在的效应修饰。
与最低四分位数相比，血清β-六氯环己烷和总滴滴涕最高四分位数的参与者患MASLD的几率分别高2.48倍和1.95倍[模型3：β-六氯环己烷的OR（95%CI）=2.48（1.37，4.56），总滴滴涕的OR（95%CI）=1.95（1.20，3.21）]。虽然β-六氯环己烷与新发MASLD呈线性关联，但总滴滴涕呈非线性关系（非线性P=0.044）。分层分析表明，该关联不会因人口统计学或生活方式因素而有显著改变。同时，与两者水平都低的个体相比，β-六氯环己烷和总滴滴涕水平都高的个体患MASLD的几率最高[OR（95%CI）=2.90（1.66，5.18）]。
这项纵向研究表明，较高水平的β-六氯环己烷和总滴滴涕与患MASLD几率增加有关，存在正向联合效应。需要更多关注OCP共同暴露的有害影响以及加速OCP的清除。
