The ASO drug olezarsen targets familial chylomicronemia syndrome.
作者信息
Jin Jing, Nguyen Le Tra Giang, Tawfik Sherouk M, Armanios Beshoy, Zhong Xiao-Bo
机构信息
Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269, USA.
Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269, USA.
出版信息
Trends Pharmacol Sci. 2025 Aug;46(8):814-815. doi: 10.1016/j.tips.2025.05.007. Epub 2025 Jun 5.
Abstract
摘要
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本文引用的文献
1
Olezarsen: First Approval.奥雷扎森：首次获批。
Drugs. 2025 Apr;85(4):571-576. doi: 10.1007/s40265-025-02166-0. Epub 2025 Mar 13.
2
Olezarsen, a liver-directed ASO therapy for hypertriglyceridemia.Olezarsen，一种针对高甘油三酯血症的肝脏靶向 ASO 疗法。
Expert Opin Pharmacother. 2024 Oct;25(14):1861-1866. doi: 10.1080/14656566.2024.2408369. Epub 2024 Sep 26.
3
Mechanisms of Action of the US Food and Drug Administration-Approved Antisense Oligonucleotide Drugs.美国食品和药物管理局批准的反义寡核苷酸药物的作用机制。
BioDrugs. 2024 Jul;38(4):511-526. doi: 10.1007/s40259-024-00665-2. Epub 2024 Jun 25.
4
Olezarsen for Hypertriglyceridemia in Patients at High Cardiovascular Risk.Olezarsen 治疗心血管疾病高危患者的高三酰甘油血症。
N Engl J Med. 2024 May 16;390(19):1770-1780. doi: 10.1056/NEJMoa2402309. Epub 2024 Apr 7.
5
Olezarsen, Acute Pancreatitis, and Familial Chylomicronemia Syndrome.奥列扎森，急性胰腺炎和家族性乳糜微粒血症综合征。
N Engl J Med. 2024 May 16;390(19):1781-1792. doi: 10.1056/NEJMoa2400201. Epub 2024 Apr 7.
6
Recent advances in treating hypertriglyceridemia in patients at high risk of cardiovascular disease with apolipoprotein C-III inhibitors.新型载脂蛋白 C-III 抑制剂治疗心血管疾病高危患者高甘油三酯血症的研究进展。
Expert Opin Pharmacother. 2023 Jun;24(9):1013-1020. doi: 10.1080/14656566.2023.2206015. Epub 2023 Apr 28.
7
Apolipoprotein C-III reduction in subjects with moderate hypertriglyceridaemia and at high cardiovascular risk.载脂蛋白 C-III 降低可降低心血管风险高危的中度高甘油三酯血症患者风险。
Eur Heart J. 2022 Apr 6;43(14):1401-1412. doi: 10.1093/eurheartj/ehab820.
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