Falk Jonathan, Falk Stephan, Krenn Veit
MVZ für Histologie, Zytologie und Molekulare Diagnostik Trier GmbH, Max-Planck-Str. 5, 54296, Trier, Deutschland.
Z Rheumatol. 2025 Jun 6. doi: 10.1007/s00393-025-01657-5.
Amyloidosis denotes a group of rare, but often fatal diseases which result from abnormal folding and deposition of insoluble proteins with subsequent organ damage especially of the heart and the kidneys. Histologic identification of amyloid by Congo red staining and by immunohistochemistry in the musculoskeletal system by orthopedic pathology especially in specimens from surgery for carpal tunnel syndrome, lumbar spinal stenosis and spontaneous tendon rupture, but also from other sites of the musculoskeletal system may facilitate early diagnosis and treatment of amyloidosis. Appropriate techniques for the detection of amyloid should be included in the routine diagnostic workup of all rheumatologic pathology specimens.
淀粉样变性是指一组罕见但往往致命的疾病，这些疾病是由不溶性蛋白质异常折叠和沉积导致的，随后会造成器官损害，尤其是心脏和肾脏。通过刚果红染色和免疫组织化学在肌肉骨骼系统中对淀粉样蛋白进行组织学鉴定，特别是在腕管综合征、腰椎管狭窄症和自发性肌腱断裂手术标本中，也在肌肉骨骼系统的其他部位，这可能有助于淀粉样变性的早期诊断和治疗。检测淀粉样蛋白的适当技术应纳入所有风湿性病理标本的常规诊断检查中。
