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分子成像在头颈部原发灶不明患者中检测到的非氟代脱氧葡萄糖（FDG）摄取性转移灶

Non-FDG-Avid Metastasis Detected by Molecular Imaging in Unknown Primary of the Head and Neck.

作者信息

Meeks Nicole, McAdoo Ashtyn, Lee Jaclyn, Hom Marisa, Smith Gary, Hicks Melanie, Mannion Kyle, Rosenthal Eben, Topf Michael C

机构信息

Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Department of Nuclear Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

出版信息

Laryngoscope. 2025 Sep;135(9):3229-3231. doi: 10.1002/lary.32228. Epub 2025 Jun 7.

DOI:10.1002/lary.32228
PMID:40481798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12371786/
Abstract

Squamous cell carcinoma of unknown primary continues to be a diagnostic challenge. We present a case where a novel molecular imaging agent aided the identification of additional lesions missed on traditional imaging, ultimately leading to diagnosis and a change in management.

摘要

原发灶不明的鳞状细胞癌仍然是一个诊断难题。我们报告了一例病例，一种新型分子成像剂有助于发现传统成像遗漏的其他病灶，最终得以确诊并改变了治疗方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/690c/12371786/70175bcce7ec/LARY-135-3229-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/690c/12371786/f11b562b13c1/LARY-135-3229-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/690c/12371786/70175bcce7ec/LARY-135-3229-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/690c/12371786/f11b562b13c1/LARY-135-3229-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/690c/12371786/70175bcce7ec/LARY-135-3229-g002.jpg

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本文引用的文献

1
Head and Neck Squamous Cell Carcinoma of Unknown Primary: A Diagnostic Work-Up.头颈部不明原发灶鳞状细胞癌：诊断性检查。
Oncologist. 2024 Mar 4;29(3):192-199. doi: 10.1093/oncolo/oyad311.
2
89Zr-panitumumab Combined With 18F-FDG PET Improves Detection and Staging of Head and Neck Squamous Cell Carcinoma.89Zr-帕尼单抗联合 18F-FDG PET 提高头颈部鳞状细胞癌的检测和分期。
Clin Cancer Res. 2022 Oct 14;28(20):4425-4434. doi: 10.1158/1078-0432.CCR-22-0094.
3
Diagnosis and Management of Squamous Cell Carcinoma of Unknown Primary in the Head and Neck: ASCO Guideline.
头颈部不明原发灶鳞状细胞癌的诊断和治疗：ASCO 指南。
J Clin Oncol. 2020 Aug 1;38(22):2570-2596. doi: 10.1200/JCO.20.00275. Epub 2020 Apr 23.
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Gemcitabine and Cisplatin Induction Chemotherapy in Nasopharyngeal Carcinoma.吉西他滨和顺铂诱导化疗治疗鼻咽癌。
N Engl J Med. 2019 Sep 19;381(12):1124-1135. doi: 10.1056/NEJMoa1905287. Epub 2019 May 31.
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Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: a meta-analysis of clinical evidence.鼻咽癌区域淋巴结转移模式：临床证据的荟萃分析。
BMC Cancer. 2012 Mar 21;12:98. doi: 10.1186/1471-2407-12-98.