Wang Chenyang, Chen Xi, Duan Lili, Chen Junfeng, Niu Liaoran, Wei Siyu, Bai Han, Zhang Yujie, Zhou Wei, Liu Jinqiang, Yang Wanli, Han Yu, Hong Liu, Fan Daiming
Department of Digestive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.
J Mol Med (Berl). 2025 Jun 7. doi: 10.1007/s00109-025-02562-9.
Poly(rC)-Binding Protein 2 (PCBP2) stands as a pivotal component within the PCBP family, renowned for its multifaceted roles in both intracellular transcriptional and post-transcriptional regulation processes. The burgeoning body of research illuminates the critical role of PCBP2 expression across a spectrum of solid malignancies. Delving into the intricacies of PCBP2's involvement in cancer genesis opens promising avenues for pioneering diagnostic techniques, therapeutic interventions, and prognostic assessments specifically tailored to gastrointestinal cancers. This review meticulously collates and examines the extant literature on PCBP2's expression dynamics and functional attributes in the oncological context, with a particular focus on gastrointestinal malignancies. Furthermore, it explores the intricate molecular pathways implicated in cancer progression where PCBP2 plays a significant role. Additionally, this discourse encapsulates the prospective clinical utilities of PCBP2, spanning diagnosis, therapeutic modalities, and prognostication in the realm of gastrointestinal cancers.
聚（rC）结合蛋白2（PCBP2）是PCBP家族中的关键成员，以其在细胞内转录和转录后调控过程中的多方面作用而闻名。不断涌现的研究揭示了PCBP2表达在一系列实体恶性肿瘤中的关键作用。深入探究PCBP2参与癌症发生的复杂机制，为专门针对胃肠道癌症的开创性诊断技术、治疗干预和预后评估开辟了广阔前景。本综述精心整理并审视了关于PCBP2在肿瘤学背景下的表达动态和功能特性的现有文献，特别关注胃肠道恶性肿瘤。此外，还探讨了PCBP2在癌症进展中发挥重要作用的复杂分子途径。此外，本文阐述了PCBP2在胃肠道癌症领域的潜在临床应用，包括诊断、治疗方式和预后评估。
