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保守治疗的慢性硬膜下血肿会怎样。

What happens to conservatively managed chronic subdural haematoma.

作者信息

Read Jack, Edlmann Ellie

机构信息

University of Exeter Medical School, Exeter, UK.

Peninsula Medical School, Faculty of Health, University of Plymouth, Plymouth, UK.

出版信息

Acta Neurochir (Wien). 2025 Jun 7;167(1):164. doi: 10.1007/s00701-025-06577-6.

Abstract

BACKGROUND

Chronic subdural haematoma (CSDH) is a common neurosurgical problem, increasingly prevalent due to an ageing population. Conservative management is an option for asymptomatic or mild cases, though data on outcomes is limited.

AIM/OBJECTIVE: This study aims to address critical gaps in understanding around conservatively managedCSDH and whether there are features that can predict progression and the longer-term prognosis of these patients.

METHODS

A retrospective cohort study was performed at a major trauma centre in the UK. All patients with chronic subdural haematoma referred from March 2019 to March 2021 were included and grouped into surgical or conservative management. Demographic, outcome, and radiological data were collected from patient records and compared.

RESULTS

Of 289 patients, 90 had surgery and 199 were managed conservatively. Conservative patients were older (84 vs 77 years, p < 0.0001), had more comorbidities (4 vs 2, p < 0.0001), higher frailty (CFS > 6: 45% vs 10%, p < 0.0001), and greater anti-thrombotic use (57% vs 42%, p = 0.0175). Mortality was significantly higher in the conservative group at all time points including one month (16% vs 2%, p < 0.0001), one year (42% vs 12%, p < 0.0001) and two years (55% vs 21%, P < 0.0001). Surgical patients had significantly greater midline shift (10 mm vs 2.6 mm, p < 0.0001), and haematoma depth (24 mm vs 11 mm, p < 0.0001). Only 3% of conservative patients crossed over to surgery.

CONCLUSION

Our study highlights the high mortality rate in conservatively managed CSDH, with frailty as a key indicator for early death. The low crossover to surgery questions the necessity of radiological monitoring in conservatively managed CSDH.

摘要

背景

慢性硬膜下血肿(CSDH)是一个常见的神经外科问题,随着人口老龄化,其发病率日益增加。对于无症状或症状轻微的病例,保守治疗是一种选择,不过关于治疗结果的数据有限。

目的

本研究旨在填补对保守治疗的CSDH认识上的关键空白,以及是否存在能够预测这些患者病情进展和长期预后的特征。

方法

在英国一家主要创伤中心进行了一项回顾性队列研究。纳入2019年3月至2021年3月转诊的所有慢性硬膜下血肿患者,并分为手术治疗组或保守治疗组。从患者记录中收集人口统计学、治疗结果和放射学数据并进行比较。

结果

289例患者中,90例行手术治疗,199例接受保守治疗。保守治疗的患者年龄更大(84岁对77岁,p<0.0001),合并症更多(4种对2种,p<0.0001),虚弱程度更高(临床衰弱量表评分>6分:45%对10%,p<0.0001),抗血栓药物使用更频繁(57%对42%,p=0.0175)。在所有时间点,保守治疗组的死亡率均显著更高,包括1个月时(16%对2%,p<0.0001)、1年时(42%对12%,p<0.0001)和2年时(55%对21%,P<0.0001)。手术治疗的患者中线移位更明显(10毫米对2.6毫米,p<0.0001),血肿深度更深(24毫米对11毫米,p<0.0001)。只有3%的保守治疗患者转为手术治疗。

结论

我们的研究强调了保守治疗的CSDH患者死亡率高,虚弱是早期死亡的关键指标。转为手术治疗的比例低,这对保守治疗的CSDH患者进行放射学监测的必要性提出了质疑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebf3/12145291/074f4e92ebb5/701_2025_6577_Fig1_HTML.jpg

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