Glavin G B
Pharmacol Biochem Behav. 1985 Sep;23(3):379-83. doi: 10.1016/0091-3057(85)90009-7.
Methylphenidate (5, 10, or 20 mg/kg/day) or saline were administered to rats in the activity-stress ulcer paradigm. Running-wheel activity and food consumption did not differ among groups. Methylphenidate produced dose-related increases in gastric ulcer severity, decreases in hypothalamic noradrenaline (NA) and increases in 3-methoxy-4-hydroxy-phenylethyleneglycol sulfate (MHPG-SO4) in the hypothalamus, amygdala, hippocampus and thalamus. These results differ markedly from the effects seen with a related substance, d-amphetamine, and suggest different mechanisms of action for these drugs.
在活动-应激性溃疡模型中，给大鼠施用哌甲酯（5、10或20毫克/千克/天）或生理盐水。各组之间的转轮活动和食物消耗没有差异。哌甲酯使胃溃疡严重程度呈剂量相关增加，使下丘脑去甲肾上腺素（NA）减少，并使下丘脑、杏仁核、海马体和丘脑的3-甲氧基-4-羟基-苯乙二醇硫酸盐（MHPG-SO4）增加。这些结果与相关物质d-苯丙胺的作用明显不同，表明这些药物的作用机制不同。
