一些新型脒衍生物作为强效降血糖剂的合成。

Synthesis of some new amidine derivatives as potent hypoglycemic agents.

作者信息

Pandeya S N, Srivastava V

出版信息

Pharmacol Res Commun. 1985 Aug;17(8):699-709. doi: 10.1016/0031-6989(85)90087-6.

Abstract

A series of S-arylformamidino-N-(alkyl/arylisothiourea) Cyclicamino dihydrochlorides were synthesised and screened for their hypoglycemic activity in normal as well as alloxanized diabetic rats. Some of the compounds (Id, Ie, Ih-1) showed more than 30% lowering of blood sugar level of Albino rats.

摘要

合成了一系列S-芳基甲脒基-N-（烷基/芳基异硫脲）环氨基二盐酸盐，并在正常大鼠和四氧嘧啶诱导的糖尿病大鼠中筛选其降血糖活性。一些化合物（Id、Ie、Ih-1）使白化大鼠的血糖水平降低了30%以上。