术后放疗延迟及治疗机构地点对头颈部癌患者生存的影响
Impact of Postoperative Radiation Therapy Delay and Treatment Facility Location on Survival in Head and Neck Cancer Patients.
作者信息
Vivek Niketna, Sharma Rahul, Prasad Kavita, Mannion Kyle, Sinard Robert J, Langerman Alexander, Rosenthal Eben, Rohde Sarah, Whitaker Ryan, Lockney Natalie, Topf Michael C
机构信息
Vanderbilt School of Medicine, Nashville, Tennessee, USA.
Department of Otolaryngology-Head & Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
出版信息
Head Neck. 2025 Jul;47(7):1807-1815. doi: 10.1002/hed.28092. Epub 2025 Jan 31.
BACKGROUND
Time from surgery to initiation of postoperative radiation therapy (PORT) of less than 6 weeks was recently instituted as the first quality metric within head and neck cancer care.
METHODS
We performed a retrospective single institution cohort study to investigate predictors of PORT delay and the impact of PORT delay on survival.
RESULTS
PORT delay rate was 73.2%, with a median time to treatment initiation of 51 days. Outside radiation facility treatment was independently associated with increased likelihood of PORT delay (OR 1.94, 95% CI 1.03-3.74, p = 0.043). PORT delay and location of radiation treatment did not impact OS or PFS.
CONCLUSIONS
In this single institution study, most patients experienced PORT delay. Patients that were treated at outside radiation facilities were more likely to experience delay. However, PORT delay did not result in statistically significant difference in OS and PFS which contrasts with the current literature.
背景
手术至术后放疗（PORT）开始的时间少于6周，最近被确立为头颈癌护理中的首个质量指标。
方法
我们进行了一项回顾性单机构队列研究，以调查PORT延迟的预测因素以及PORT延迟对生存的影响。
结果
PORT延迟率为73.2%，治疗开始的中位时间为51天。外部放疗机构治疗与PORT延迟可能性增加独立相关（OR 1.94，95%CI 1.03 - 3.74，p = 0.043）。PORT延迟和放疗位置对总生存期（OS）或无进展生存期（PFS）无影响。
结论
在这项单机构研究中，大多数患者经历了PORT延迟。在外部放疗机构接受治疗的患者更有可能经历延迟。然而，PORT延迟在OS和PFS方面并未导致统计学上的显著差异，这与当前文献相反。
Zotero 插件