Harper Diane M, Navarro-Alonso José A, Bosch F Xavier, Paavonen Jorma, Stanley Margaret, Sasieni Peter, Yébenes María, Martínez-Martínez Néstor, Rodriguez Ángela, García Andrea, Martín-Gomez Laura, Vallejo-Aparicio Laura, Carrión Helena, Ruiz García Yara
Family Medicine, Obstetrics & Gynecology, BioEngineering, Literature, Science and Arts, University of Michigan, Ann Arbor, MI, USA.
Honorary Consultant, Ministry of Health, Madrid, Spain.
Hum Vaccin Immunother. 2025 Dec;21(1):2497608. doi: 10.1080/21645515.2025.2497608. Epub 2025 Jun 9.
Cervical cancer is a preventable disease for which vaccines are available to provide long-term protection against human papillomavirus (HPV) infection. This systematic literature review (SLR) was performed to summarize the efficacy, effectiveness, impact, duration of protection, and safety profile of four licensed HPV vaccines against infection, precursor lesions, and cervical cancer. Data was extracted from published reports. The search resulted in 1,136 studies, of which 54 were selected for this review. A substantial decrease in the prevalence of oncogenic HPV types, high-grade cervical lesions, and cervical cancer was found in countries with high vaccine coverage and routine vaccination programs. Post-licensure studies of HPV vaccines have reported high efficacy, effectiveness, and health impact across settings and age groups. Studies emphasize vaccination in younger age groups. These findings may inform future discussions about HPV vaccination strategies.
宫颈癌是一种可预防的疾病，现有疫苗可提供长期保护以预防人乳头瘤病毒（HPV）感染。本系统文献综述（SLR）旨在总结四种已获许可的HPV疫苗在预防感染、癌前病变和宫颈癌方面的疗效、有效性、影响、保护持续时间及安全性。数据从已发表的报告中提取。检索结果为1136项研究，其中54项被选入本综述。在疫苗接种覆盖率高且有常规疫苗接种计划的国家，致癌性HPV类型、高级别宫颈病变和宫颈癌的患病率大幅下降。HPV疫苗的上市后研究报告了在不同环境和年龄组中的高效性、有效性及对健康的影响。研究强调在较年轻年龄组中进行疫苗接种。这些发现可能为未来关于HPV疫苗接种策略的讨论提供参考。
