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胃癌与癌症相关成纤维细胞关系的热点与前沿：一项文献计量分析

Hotspots and frontiers of the relationship between gastric cancer and cancer-associated fibroblasts: a bibliometric analysis.

作者信息

Hu Xiangcheng, Ren Lingling, Zhu Shuyuan, Shen Haiping, Qian Chengyong, Chen Guanglan, Chen Fangling

机构信息

Digestive Endoscopy Center, The Second People's Hospital of Lishui, Lishui, China.

出版信息

Front Oncol. 2025 May 23;15:1576696. doi: 10.3389/fonc.2025.1576696. eCollection 2025.

DOI:10.3389/fonc.2025.1576696
PMID:40485724
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12140985/
Abstract

BACKGROUND: Cancer-Associated Fibroblasts (CAFs) are pivotal stromal constituents within the Tumor Microenvironment (TME), characterized by marked heterogeneity and plasticity. Over the past two decades, a notable association between Gastric Cancer (GC) and CAFs has been established. Despite this, there remains a paucity of comprehensive data to guide researchers in understanding the prevalence and potential research trajectories concerning GC and CAFs. METHODS: This study conducted an extensive literature search within the Web of Science Core Collection database from January 1, 2003, to December 31, 2023. Bibliometric analysis and visualization were performed using VOSviewer, CiteSpace, R software, and Microsoft Excel. RESULTS: A total of 1170 articles were included. These articles were disseminated across 200 journals and incorporated 1800 distinct keywords. A notable surge in publications has been observed from 2011 to 2023. China emerged as the leading contributor to both article count and citations. Prominent research institutions in this domain include Osaka City University, Shanghai Jiaotong University, and National Cancer Research Center Hospital. Notable researchers, such as Masakazu Yashiro and Kosei Hirakawa from Osaka City University and Zhenggang Zhu from Shanghai Jiaotong University, were among the most productive and highly cited authors. FRONTIERS IN ONCOLOGY boasts the highest number of publications, whereas ONCOGENE ranks as the most cited journal. The primary research foci within the realm of CAFs and GC encompass the impact of CAFs on GC cell proliferation, angiogenesis, invasion, metastasis, epithelial-mesenchymal transition, immunosuppression, drug resistance, and the interplay between CAFs and GC. CONCLUSION: Using bibliometric analysis, this study presents a panoramic view of the research landscape of CAFs and GC from 2003 to 2023. It highlights prominent research areas and anticipates future directions with the aim of offering valuable insights and strategic recommendations for future endeavors in this field.

摘要

背景：癌症相关成纤维细胞（CAFs）是肿瘤微环境（TME）中的关键基质成分，具有显著的异质性和可塑性。在过去二十年中，胃癌（GC）与CAFs之间已建立了显著关联。尽管如此，仍缺乏全面的数据来指导研究人员了解有关GC和CAFs的患病率及潜在研究方向。 方法：本研究于2003年1月1日至2023年12月31日在Web of Science核心合集数据库中进行了广泛的文献检索。使用VOSviewer、CiteSpace、R软件和Microsoft Excel进行文献计量分析和可视化。 结果：共纳入1170篇文章。这些文章发表在200种期刊上，包含1800个不同的关键词。2011年至2023年期间观察到出版物数量显著增加。中国在文章数量和引用次数方面均成为主要贡献者。该领域的知名研究机构包括大阪市立大学、上海交通大学和国立癌症研究中心医院。来自大阪市立大学的Masakazu Yashiro和Kosei Hirakawa以及上海交通大学的朱正纲等知名研究人员是产出最多且被引用次数最多的作者。《肿瘤前沿》的出版物数量最多，而《癌基因》则是被引用次数最多的期刊。CAFs和GC领域的主要研究重点包括CAFs对GC细胞增殖、血管生成、侵袭、转移、上皮-间质转化、免疫抑制、耐药性的影响以及CAFs与GC之间的相互作用。 结论：本研究通过文献计量分析呈现了2003年至2023年CAFs和GC研究领域的全景。它突出了突出的研究领域并预测了未来方向，旨在为该领域的未来努力提供有价值的见解和战略建议。

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本文引用的文献

[1]
Diagnosis of mental disorders using machine learning: Literature review and bibliometric mapping from 2012 to 2023.

Heliyon. 2024-6-8

[2]
A bibliometric analysis of gastric cancer liver metastases: advances in mechanisms of occurrence and treatment options.

Int J Surg. 2024-4-1

[3]
A bibliometric and visual analysis of cancer-associated fibroblasts.

Front Immunol. 2023

[4]
Cancer-Associated Fibroblast-Derived IL-8 Upregulates PD-L1 Expression in Gastric Cancer Through the NF-κB Pathway.

Ann Surg Oncol. 2024-5

[5]
Downregulation of cancer-associated fibroblast exosome-derived miR-29b-1-5p restrains vasculogenic mimicry and apoptosis while accelerating migration and invasion of gastric cancer cells via immunoglobulin domain-containing 1/zonula occluden-1 axis.

Cell Cycle. 2023-9

[6]
Cancer associated fibroblast derived SLIT2 drives gastric cancer cell metastasis by activating NEK9.

Cell Death Dis. 2023-7-13

[7]
Evolution of immune and stromal cell states and ecotypes during gastric adenocarcinoma progression.

Cancer Cell. 2023-8-14

[8]
POSTN Secretion by Extracellular Matrix Cancer-Associated Fibroblasts (eCAFs) Correlates with Poor ICB Response via Macrophage Chemotaxis Activation of Akt Signaling Pathway in Gastric Cancer.

Aging Dis. 2023-12-1

[9]
Epigenetic regulation of cancer-associated fibroblast heterogeneity.

Biochim Biophys Acta Rev Cancer. 2023-5

[10]
CAFs orchestrates tumor immune microenvironment-A new target in cancer therapy?

Front Pharmacol. 2023-3-14

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