Department of Urology Surgery.
The First Laboratory of Cancer Institute.
Int J Surg. 2024 Apr 1;110(4):2288-2299. doi: 10.1097/JS9.0000000000001068.
Gastric cancer (GC) is the fifth most commonly diagnosed cancer worldwide, and its poor prognosis is predominantly attributed to distant metastasis. The liver is the primary site of GC metastasis. However, there is no universally approved treatment regimen for liver metastasis in GC. The aim of this article is to review the current research status and trends of liver metastasis of GC worldwide.
The authors utilized the Web of Science Core Collection database to identify articles on liver metastasis from GC published between 2000 and 2022. The authors used bibliometric methods to analyze authors, institutions, countries, journals, and references through CiteSpace and VOSviewer. A total of 1003 articles were included in this study.
Japan published the most articles in the field, followed by China. Nagoya University is the leading institution in the field of liver metastases in GC. Yasuhiro Kodera from Japan has made significant achievements in this area. The authors identified GC to be the most influential journal in this field. Using cluster analysis, the keywords were divided into four major clusters:(1) the molecular mechanism of GC liver metastasis, (2) prognosis, (3) liver resection, and (4) chemotherapy.
Our study systematically summarizes the results of GC liver metastasis research from 2000 to 2022 and describes and predicts research hotspots and trends on a global scale. Research on the molecular mechanisms of GC liver metastasis will become a hot topic in the future, and the expansion of the surgical treatment scope and the advancement of translational therapy will benefit more patients.
胃癌（GC）是全球第五大常见癌症，其预后不良主要归因于远处转移。肝脏是 GC 转移的主要部位。然而，对于 GC 的肝转移，目前尚无普遍认可的治疗方案。本文旨在综述全球 GC 肝转移的研究现状和趋势。
作者利用 Web of Science 核心合集数据库，检索了 2000 年至 2022 年间发表的关于 GC 肝转移的文章。作者采用文献计量学方法，通过 CiteSpace 和 VOSviewer 对作者、机构、国家、期刊和参考文献进行分析。本研究共纳入 1003 篇文章。
日本发表的相关文章最多，其次是中国。名古屋大学是 GC 肝转移领域的领先机构。日本的Yasuhiro Kodera 在该领域取得了显著成就。作者发现《GC》是该领域最具影响力的期刊。通过聚类分析，关键词可分为四个主要聚类：（1）GC 肝转移的分子机制，（2）预后，（3）肝切除术，（4）化疗。
本研究系统总结了 2000 年至 2022 年 GC 肝转移研究的结果，并描述和预测了全球范围内的研究热点和趋势。GC 肝转移分子机制的研究将成为未来的热点，扩大手术治疗范围和推进转化治疗将使更多患者受益。
