Dean Marleah, Jowers Bethany, Conley Claire, Camacho Erica, Espinel Whitney, Kaphingst Kimberly A
Department of Communication, University of South Florida, Tampa, FL, USA.
Health Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, FL, USA.
PEC Innov. 2025 May 10;6:100402. doi: 10.1016/j.pecinn.2025.100402. eCollection 2025 Jun.
Previvors-unaffected individuals who have increased risk of cancer due to a pathogenic or likely pathogenic variant in a gene-experience high levels of uncertainty, which is associated with negative outcomes. The ePOWER (empowering Preventive Options for Women Experiencing Risk) intervention is designed to help previvors manage their cancer-related uncertainty and make informed health decisions. In this study, we assessed the acceptability of ePOWER using a multiple methods approach.
Previvors ( = 24) completed individual, semi-structured interviews. Previvors first completed the Treatment Acceptability and Preference Scale (TAPS). Additionally, using a Learner Verification & Revision (LV&R) interviewing approach, we also elicited feedback on whether ePOWER was understandable, salient, and satisfactory to previvors. Acceptability was assessed by quantitative data (TAPS scores) and qualitative data (interviews). In analyzing the interview data and integrating the findings, deductive coding was utilized using LV&R categories and inductive thematic analysis was utilized to capture additional nuances from participants' evaluation.
Adequate acceptability was demonstrated by TAPS scores. 88 % of participants exceeded the a priori acceptability threshold (TAPS ≥3). Deductive coding using LV&R categories also confirmed ePOWER was visually appealing, understandable, persuasive, cultural appropriate, and fostered self-efficacy. Inductive thematic analysis expanded on the LV&R categories and identified two additional themes: (1) relatability and emotional support and (2) useful resource.
ePOWER is an acceptable intervention to help previvors manage cancer-related uncertainty and support decision making.
The ePOWER intervention can be shared during healthcare appointments and then utilized continuously by previvors to manage uncertainty and facilitate decisions.
癌症高危个体（即因基因中的致病或可能致病变异而患癌风险增加的未患病个体）经历着高度的不确定性，这与负面结果相关。ePOWER（增强面临风险女性的预防选择能力）干预旨在帮助癌症高危个体应对与癌症相关的不确定性，并做出明智的健康决策。在本研究中，我们采用多种方法评估了ePOWER的可接受性。
24名癌症高危个体完成了个人半结构化访谈。这些个体首先完成了治疗可接受性和偏好量表（TAPS）。此外，我们采用学习者验证与修订（LV&R）访谈方法，就ePOWER对癌症高危个体而言是否易懂、突出且令人满意征求了反馈意见。通过定量数据（TAPS评分）和定性数据（访谈）评估可接受性。在分析访谈数据并整合研究结果时，使用LV&R类别进行演绎编码，并采用归纳主题分析来捕捉参与者评估中的其他细微差别。
TAPS评分表明ePOWER具有足够的可接受性。88%的参与者超过了先验可接受阈值（TAPS≥3）。使用LV&R类别进行的演绎编码也证实，ePOWER在视觉上具有吸引力、易懂、有说服力、符合文化背景且能增强自我效能感。归纳主题分析在LV&R类别基础上进行了拓展，确定了另外两个主题：（1）相关性和情感支持；（2）有用的资源。
ePOWER是一种可接受的干预措施，有助于癌症高危个体应对与癌症相关的不确定性并支持决策制定。
ePOWER干预可在医疗预约期间进行分享，然后由癌症高危个体持续使用，以应对不确定性并促进决策制定。
