Suppr超能文献

髋部疼痛——小儿年龄组广泛深静脉血栓形成(DVT)的罕见原因:一例报告

Hip pain - an uncommon cause of extensive deep vein thrombosis (DVT) in the paediatric age group: a case report.

作者信息

DaCosta Adebayo, Gurung Suprina, Osonuga Ayokunle, DaCosta Demilade, Adegbite Moyoninuoluwa

机构信息

Department of Emergency Medicine, Medway Maritime Hospital, Gillingham, Kent, United Kingdom.

Department of General Practice, Coltishall Medical Practice, Coltishall, Norfolk, United Kingdom.

出版信息

Pan Afr Med J. 2025 Mar 11;50:69. doi: 10.11604/pamj.2025.50.69.46977. eCollection 2025.

Abstract

Deep vein thrombosis (DVT) in the pediatric population remains an infrequent yet clinically significant entity, with an estimated incidence of 0.07-0.14 per 10,000 children. We describe a unique case involving a previously healthy 16-year-old female who presented with progressively worsening left hip pain radiating to the knee, inability to weight bear, and associated limb heaviness with a purple discoloration on standing. Clinical evaluation revealed unilateral leg swelling, increased girth, and pain on passive joint movement, while initial radiographs were unremarkable; however, a markedly elevated D-dimer level prompted further investigation with Doppler ultrasound, which confirmed an extensive iliofemoral DVT. Owing to the lack of pediatric-specific guidelines, management was adapted from adult protocols, including thrombolytic therapy with tissue plasminogen activator and subsequent anticoagulation with dalteparin and apixaban, despite a complication of epistaxis that influenced the treatment course. This case highlights the diagnostic challenges inherent in pediatric DVT, highlights the necessity for a high index of suspicion when evaluating hip or leg pain in children, and emphasizes the urgent need for the development of dedicated pediatric guidelines to inform optimal therapeutic strategies.

摘要

儿童深静脉血栓形成(DVT)仍然是一种罕见但具有临床意义的病症,估计每10000名儿童中的发病率为0.07 - 0.14。我们描述了一个独特的病例,一名此前健康的16岁女性,出现左髋部疼痛逐渐加重并放射至膝盖,无法负重,站立时伴有肢体沉重感及紫色瘀斑。临床评估发现单侧腿部肿胀、周长增加以及被动关节活动时疼痛,而最初的X线片无明显异常;然而,D - 二聚体水平显著升高促使进一步进行多普勒超声检查,结果证实为广泛的髂股静脉DVT。由于缺乏针对儿童的指南,治疗方案参照成人方案,包括使用组织纤溶酶原激活剂进行溶栓治疗,随后使用达肝素和阿哌沙班进行抗凝治疗,尽管出现了鼻出血这一影响治疗进程的并发症。该病例凸显了儿童DVT固有的诊断挑战,强调在评估儿童髋部或腿部疼痛时高度怀疑的必要性,并强调迫切需要制定专门的儿童指南以指导最佳治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fba/12143306/37e548eb8d14/PAMJ-50-69-g001.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验