16S rRNA sequencing data of fecal microbiota from juvenile female rats following prenatal poly I:C exposure.

With the expanding insights into the "gut-brain axis," the association between neurodevelopmental disorders (NDDs) and gut microbiota has gained extensive attention in scientific research. Maternal immune activation (MIA) in pregnant females is a crucial environmental risk factor for NDDs in offspring. Polyriboinosinic-polyribocytidylic acid (Poly I:C) belongs to a class of synthetic analogs of double-stranded RNA used to induce MIA in rodents and is widely used in scientific research. The dataset presents 16S rRNA sequencing data of fecal microbiota from juvenile female rats following prenatal Poly I:C exposure. It will help to clarify the impact of prenatal Poly I:C exposure on the intestinal microbiota characteristics of juvenile female offspring rats, reveal the role of the intestinal microbiota in the pathophysiological changes related to maternal immune activation and provide new insights into the mechanism of the microbiota-gut-brain axis in neurodevelopmental disorders.