Yang Lirong, Chen Huiyu, Zeng Menglu, Lu Yanfang, Xu Chen, Cao Zhenju, Zhong Fuchun, Yang Xinyu, Shen Anying, Xue Fei, Lin Wei, Cao Hua, Deng Chao, Su Yueqing
School of Public Health, Fujian Medical University, Fuzhou, China.
Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Data Brief. 2025 May 1;60:111588. doi: 10.1016/j.dib.2025.111588. eCollection 2025 Jun.
With the expanding insights into the "gut-brain axis," the association between neurodevelopmental disorders (NDDs) and gut microbiota has gained extensive attention in scientific research. Maternal immune activation (MIA) in pregnant females is a crucial environmental risk factor for NDDs in offspring. Polyriboinosinic-polyribocytidylic acid (Poly I:C) belongs to a class of synthetic analogs of double-stranded RNA used to induce MIA in rodents and is widely used in scientific research. The dataset presents 16S rRNA sequencing data of fecal microbiota from juvenile female rats following prenatal Poly I:C exposure. It will help to clarify the impact of prenatal Poly I:C exposure on the intestinal microbiota characteristics of juvenile female offspring rats, reveal the role of the intestinal microbiota in the pathophysiological changes related to maternal immune activation and provide new insights into the mechanism of the microbiota-gut-brain axis in neurodevelopmental disorders.
随着对“肠-脑轴”的认识不断深入，神经发育障碍（NDDs）与肠道微生物群之间的关联在科学研究中受到了广泛关注。怀孕女性的母体免疫激活（MIA）是后代患NDDs的一个关键环境风险因素。聚肌苷酸-聚胞苷酸（Poly I:C）属于一类双链RNA的合成类似物，用于在啮齿动物中诱导MIA，在科学研究中被广泛使用。该数据集呈现了产前暴露于Poly I:C的幼年雌性大鼠粪便微生物群的16S rRNA测序数据。这将有助于阐明产前暴露于Poly I:C对幼年雌性后代大鼠肠道微生物群特征的影响，揭示肠道微生物群在与母体免疫激活相关的病理生理变化中的作用，并为神经发育障碍中微生物群-肠-脑轴的机制提供新的见解。
