Georgakopoulou Vasiliki Epameinondas, Lazaridou Athina, Voulgaris Athanasios, Archontogeorgis Kostas, Dalamaga Maria, Nena Evangelia, Steiropoulos Paschalis
Medical School, Democritus University of Thrace, 68100, Alexandroupolis, Greece.
Department of Pathophysiology, Laiko General Hospital, National and Kapodistrian University of Athens, 11527, Athens, Greece.
Metabol Open. 2025 May 4;26:100367. doi: 10.1016/j.metop.2025.100367. eCollection 2025 Jun.
Only a few studies in the published literature have assessed the well-being, and the sleep quality (SQ) in patients with obesity hypoventilation syndrome (OHS). The aim of this study was to evaluate well-being and SQ in patients with OHS and to compare these outcomes with those of patients with obstructive sleep apnea (OSA) and obesity.
Consecutive subjects being referred for evaluation of sleep disordered breathing were enrolled in the study. Patients were divided into two groups: Group A: OSA patients with BMI ≥30 kg/m and 2) Group B: OHS patients. Well-being was assessed using the World Health Organization-Five Well-Being Index (WHO-5), while sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI).
In total 1010 participants (OHS, n = 203) were included in the study. No difference was observed between groups in mean scores of Epworth Sleepiness Scale (ESS), Fatigue Severity Scale (FSS), WHO-5, and PSQI questionnaires. In patients with OHS, WHO-5 score was negatively correlated with neck circumference (r = -0.703, p = 0.016) and waist circumference (r = -0.728, p = 0.011). Moreover, PSQI scores in this group were significantly correlated with BMI (r = 0.410, p = 0.038). A lower WHO-5 score was observed in OHS patients with diabetes mellitus compared to non-diabetic patients with OHS (p = 0.049).
Patients with OSA and OHS reported similarly poor well-being and SQ. In patients with OHS, both high neck - and waist circumference were associated with poor well-being, while higher BMI was associated with worse sleep quality. Additionally, the well-being of OHS patients with concomitant diabetes mellitus was worse compared to OHS patients without diabetes mellitus.
已发表文献中仅有少数研究评估了肥胖低通气综合征（OHS）患者的健康状况和睡眠质量（SQ）。本研究的目的是评估OHS患者的健康状况和SQ，并将这些结果与阻塞性睡眠呼吸暂停（OSA）患者和肥胖患者的结果进行比较。
连续入选因睡眠呼吸障碍接受评估的受试者。患者分为两组：A组：BMI≥30 kg/m²的OSA患者；2）B组：OHS患者。使用世界卫生组织-五福健康指数（WHO-5）评估健康状况，使用匹兹堡睡眠质量指数（PSQI）评估睡眠质量。
本研究共纳入1010名参与者（OHS患者203名）。两组在爱泼沃斯嗜睡量表（ESS）、疲劳严重程度量表（FSS）、WHO-5和PSQI问卷的平均得分上未观察到差异。在OHS患者中，WHO-5得分与颈围（r = -0.703，p = 0.016）和腰围（r = -0.728，p = 0.011）呈负相关。此外，该组的PSQI得分与BMI显著相关（r = 0.410，p = 0.038）。与非糖尿病OHS患者相比，糖尿病OHS患者的WHO-5得分更低（p = 0.049）。
OSA和OHS患者报告的健康状况和SQ同样较差。在OHS患者中，高颈围和腰围均与健康状况差相关，而较高的BMI与较差的睡眠质量相关。此外，与无糖尿病的OHS患者相比，合并糖尿病的OHS患者的健康状况更差。
