Sridhar S, Narendiran Sandhiya, K R Murugan, Marimuthu A, Adalarasan Sahasyaa, S Yogesh, Shivamalarvizhi S, C Hariharan
Internal Medicine, Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai, IND.
Internal Medicine, Madras Medical College, Chennai, IND.
Cureus. 2025 May 7;17(5):e83697. doi: 10.7759/cureus.83697. eCollection 2025 May.
Calcium channel blockers (CCBs) are among the most widely prescribed drugs for cardiovascular illnesses. Angina pectoris, cardiac arrhythmias, hypertension, and other conditions are treated with calcium channel blockers (CCBs). Both immediate-release and extended-release versions of these drugs are available; the latter are often used in therapeutic settings. While extended-release CCB overdoses can cause delayed start of dysrhythmias, shock, sudden cardiac collapse, and intestinal ischemia, immediate-release CCB overdoses are characterized by rapid progression to hypotension, bradydysrhythmia, and cardiac arrest. The present case series consists of five cases of amlodipine toxicity that were treated at Rajiv Gandhi General Government Hospital and had a range of clinical manifestations. The present case series also includes two cases of non-cardiogenic pulmonary edema, a rare presentation of amlodipine poisoning.
钙通道阻滞剂（CCB）是治疗心血管疾病处方最广泛的药物之一。钙通道阻滞剂（CCB）用于治疗心绞痛、心律失常、高血压及其他病症。这些药物有速释和缓释两种剂型；后者常用于治疗。虽然缓释CCB过量可导致心律失常延迟发作、休克、心搏骤停和肠道缺血，但速释CCB过量的特征是迅速发展为低血压、缓慢性心律失常和心脏骤停。本病例系列包括在拉吉夫·甘地综合政府医院接受治疗的5例氨氯地平中毒病例，临床表现多样。本病例系列还包括2例非心源性肺水肿，这是氨氯地平中毒的一种罕见表现。
