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视神经炎作为梅毒的首发表现

Optic Neuritis As the Initial Presentation of Syphilis.

作者信息

Bonito Bruno, Cartucho Joana, Silva Monica F, Ferreira Maia Inês, Ginga Maria do Rosário

机构信息

Internal Medicine, Centro Hospitalar Barreiro Montijo, Barreiro, PRT.

出版信息

Cureus. 2025 May 8;17(5):e83704. doi: 10.7759/cureus.83704. eCollection 2025 May.

DOI:10.7759/cureus.83704
PMID:40486380
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12145498/
Abstract

Syphilis is transmitted via sexual contact and spreads through the lymphatic and hematologic systems. Ocular syphilis is an uncommon yet serious manifestation of syphilis that can cause significant vision impairment. This report presents a case of ocular syphilis in a 41-year-old otherwise healthy woman who presented with left-sided blurry vision and ocular discomfort. Examination confirmed decreased visual acuity and optic disc swelling in the left eye. Magnetic resonance imaging findings suggested optic neuritis. After ruling out other causes of optic neuritis and considering the presentation and diagnostic tests, including nontreponemal and treponemal, the diagnosis of ocular syphilis was confirmed. The patient was started on ceftriaxone and fully recovered.

摘要

梅毒通过性接触传播,并经淋巴和血液系统扩散。眼梅毒是梅毒一种不常见但严重的表现形式,可导致严重的视力损害。本报告介绍了一名41岁身体健康的女性眼梅毒病例,该患者出现左侧视力模糊和眼部不适。检查证实左眼视力下降和视盘肿胀。磁共振成像结果提示视神经炎。在排除视神经炎的其他病因并综合临床表现及包括非梅毒螺旋体和梅毒螺旋体检测在内的诊断性检查后,确诊为眼梅毒。患者开始使用头孢曲松治疗并完全康复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9447/12145498/fc98a465d5b5/cureus-0017-00000083704-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9447/12145498/fab5c6d15f18/cureus-0017-00000083704-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9447/12145498/fc98a465d5b5/cureus-0017-00000083704-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9447/12145498/fab5c6d15f18/cureus-0017-00000083704-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9447/12145498/fc98a465d5b5/cureus-0017-00000083704-i02.jpg

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本文引用的文献

1
Could ceftriaxone be a viable alternative to penicillin for the treatment of ocular syphilis?头孢曲松能否作为青霉素治疗眼梅毒的可行替代药物?
Antimicrob Agents Chemother. 2024 Jun 5;68(6):e0008024. doi: 10.1128/aac.00080-24. Epub 2024 May 6.
2
An Updated Review of Recent Advances in Neurosyphilis.神经梅毒近期进展的最新综述
Front Med (Lausanne). 2022 Sep 20;9:800383. doi: 10.3389/fmed.2022.800383. eCollection 2022.
3
Demographic, Clinical and Laboratory Characteristics of Ocular Syphilis: 6-Years Case Series Study From an Eye Center in East-China.
眼部梅毒的人口学、临床和实验室特征:华东某眼中心 6 年病例系列研究。
Front Immunol. 2022 Jun 10;13:910337. doi: 10.3389/fimmu.2022.910337. eCollection 2022.
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Ocular syphilis.眼部梅毒。
Clin Exp Optom. 2021 Sep;104(7):756-759. doi: 10.1080/08164622.2021.1906848. Epub 2021 Apr 8.
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The importance of proper and prompt treatment of ocular syphilis: a lesson from permanent vision loss in 52 eyes.正确及时治疗眼部梅毒的重要性:52 只眼致永久性视力丧失的教训。
J Eur Acad Dermatol Venereol. 2020 Jul;34(7):1569-1578. doi: 10.1111/jdv.16347. Epub 2020 Jun 25.
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Neurosyphilis presenting as visually asymptomatic bilateral optic perineuritis.表现为视觉无症状性双侧视神经周围炎的神经梅毒。
BMJ Case Rep. 2019 Dec 22;12(12):e232520. doi: 10.1136/bcr-2019-232520.
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Ocular syphilis: case series (2000-2015) from 2 tertiary care centres in Montreal, Canada.眼梅毒:来自加拿大蒙特利尔 2 家三级保健中心的病例系列(2000-2015 年)。
Can J Ophthalmol. 2020 Feb;55(1):30-37. doi: 10.1016/j.jcjo.2019.05.009. Epub 2019 Aug 5.
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Unilateral swollen optic disc: do not forget neurosyphilis.单侧视神经盘肿胀:勿忘神经梅毒。
BMJ Case Rep. 2013 Jul 9;2013:bcr2013008891. doi: 10.1136/bcr-2013-008891.
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Neurosyphilis presenting as asymptomatic optic perineuritis.表现为无症状性视神经周围炎的神经梅毒。
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Postgrad Med J. 2006 Jan;82(963):36-9. doi: 10.1136/pgmj.2004.020875.