Effect of indomethacin on the bradykinin-induced vasodilation in the submandibular gland.

Effects of the local infusion of bradykinin or isoproterenol were studied on the systemic blood pressure, blood flow, and vascular resistance of the submandibular gland before and after indomethacin treatment in cats. Both bradykinin and isoproterenol were shown to potently increase the glandular perfusion rate. The systemic arterial blood pressure fell by about 20% in response to indomethacin. The enhancement of blood flow by bradykinin or isoproterenol was not, however, affected by indomethacin treatment. The present results appear to suggest that the endogenous prostaglandins are not essentially involved in the development of responses produced by bradykinin or isoproterenol in the cat submandibular gland.