文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

逍遥丸治疗乳腺癌的药理机制分析

Analysis of the pharmacological mechanisms of Xiaoyao pill in breast cancer treatment.

作者信息

Chen Jie, Meng Xinyu, Shen Yanyan, Bhandari Adheesh, Hao Rutian

机构信息

Operating Room, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.

Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.

出版信息

Ann Med Surg (Lond). 2025 May 12;87(6):3201-3214. doi: 10.1097/MS9.0000000000003276. eCollection 2025 Jun.

DOI:10.1097/MS9.0000000000003276
PMID:40486580
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12140689/
Abstract

OBJECTIVE: The Xiaoyao pill, a Chinese patent medicine initially designed for treating breast hyperplasia, has emerged as a potential therapy for inhibiting breast cancer. METHOD: Research has delved into its mechanisms, utilizing Disease Oncology, Gene Oncology, and Kyoto Encyclopedia of Genes and Genomes analyses. Correlations between Xiaoyao pill's target genes and lipid metabolism were identified. Comparative gene set enrichment analysis between normal and breast cancer (BRCA) tissues showed down-regulation of lipid metabolism-related genes in BRCA, suggesting their role in cancer development. Weighted gene co-expression analysis revealed a gene module associated with both normal and malignant breast tissue, impacting lipid metabolism significantly. RESULT: Protein-protein interaction network analysis highlighted expression differences in 24 common genes shared between Xiaoyao pill and BRCA. Receiver operating characteristic curve analysis indicated Xiaoyao pill's potential diagnostic utility for BRCA. Target genes were detectable in immune cell types, particularly T cells, suggesting a role in tumor immunity modulation. CONCLUSION: In conclusion, the Xiaoyao pill holds promise in treating BRCA by down-regulating lipid metabolism pathways and potentially influencing tumor immunity, presenting a multifaceted approach to breast cancer management.

摘要

目的：逍遥丸是一种最初用于治疗乳腺增生的中成药，现已成为一种潜在的抑制乳腺癌的疗法。 方法：研究利用疾病肿瘤学、基因肿瘤学和京都基因与基因组百科全书分析深入探究其作用机制。确定了逍遥丸靶基因与脂质代谢之间的相关性。正常组织与乳腺癌（BRCA）组织之间的比较基因集富集分析表明，BRCA中脂质代谢相关基因下调，提示其在癌症发展中的作用。加权基因共表达分析揭示了一个与正常和恶性乳腺组织均相关的基因模块，对脂质代谢有显著影响。 结果：蛋白质-蛋白质相互作用网络分析突出了逍遥丸与BRCA共有的24个常见基因的表达差异。受试者工作特征曲线分析表明逍遥丸对BRCA具有潜在的诊断效用。在免疫细胞类型中可检测到靶基因，尤其是T细胞，提示其在肿瘤免疫调节中的作用。 结论：总之，逍遥丸有望通过下调脂质代谢途径并潜在地影响肿瘤免疫来治疗BRCA，为乳腺癌管理提供了一种多方面的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e02/12140689/2b6efb03b991/ms9-87-3201-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e02/12140689/efe2c1f79305/ms9-87-3201-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e02/12140689/82c4734bcb19/ms9-87-3201-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e02/12140689/cf7c3b858735/ms9-87-3201-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e02/12140689/73854e3be9dc/ms9-87-3201-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e02/12140689/5bfb756f8594/ms9-87-3201-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e02/12140689/704bb8446331/ms9-87-3201-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e02/12140689/6ec3096bcfd4/ms9-87-3201-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e02/12140689/b1b554deed9a/ms9-87-3201-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e02/12140689/2b6efb03b991/ms9-87-3201-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e02/12140689/efe2c1f79305/ms9-87-3201-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e02/12140689/82c4734bcb19/ms9-87-3201-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e02/12140689/cf7c3b858735/ms9-87-3201-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e02/12140689/73854e3be9dc/ms9-87-3201-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e02/12140689/5bfb756f8594/ms9-87-3201-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e02/12140689/704bb8446331/ms9-87-3201-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e02/12140689/6ec3096bcfd4/ms9-87-3201-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e02/12140689/b1b554deed9a/ms9-87-3201-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e02/12140689/2b6efb03b991/ms9-87-3201-g009.jpg

相似文献

[1]
Analysis of the pharmacological mechanisms of Xiaoyao pill in breast cancer treatment.

Ann Med Surg (Lond). 2025-5-12

[2]
[Exploration on mechanisms of Xiaoyao Powder in treating atherosclerosis and depressive disorder with concept of "treating different diseases with same method" based on network pharmacology].

Zhongguo Zhong Yao Za Zhi. 2020-9

[3]
Proprietary Medicines Containing DC. (Chaihu) for Depression: Network Meta-Analysis and Network Pharmacology Prediction.

Front Pharmacol. 2022-4-6

[4]
Development and Validation of a Prognostic Classifier Based on Lipid Metabolism-Related Genes for Breast Cancer.

J Inflamm Res. 2022-6-14

[5]
[Mechanism of Xiaoyao San in treatment of depression,breast hyperplasia,and functional dyspepsia based on network pharmacology].

Zhongguo Zhong Yao Za Zhi. 2021-8

[6]
Xiaoyao Pill Improves the Affective Dysregulation of Sleep-deprived Female Mice by Inhibiting Brain Injury and Regulating the Content of Monoamine Neurotransmitter.

Curr Pharm Biotechnol. 2022

[7]
Uncovering the effect and mechanism of Jiawei Xiaoyao Wan in treating breast cancer complicated with depression based on network pharmacology and experimental analysis.

Phytomedicine. 2024-6

[8]
Molecular targets and mechanisms of on diabetic cardiomyopathy based on network pharmacology.

World J Diabetes. 2023-11-15

[9]
Network Pharmacology and Experimental Validation Reveal Sishen Pill's Efficacy in Treating NSAID-Induced Small Intestinal Ulcers.

Drug Des Devel Ther. 2025-3-19

[10]
Based on BATMAN-TCM to Explore the Molecular Mechanism of Xihuang Pill Regulating Immune Function to Treat Breast Precancerous Lesions.

Breast Cancer (Dove Med Press). 2021-12-23

本文引用的文献

[1]
A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation.

Chin Med. 2021-11-22

[2]
Xiaoyao Pills Ameliorate Depression-like Behaviors and Oxidative Stress Induced by Olfactory Bulbectomy in Rats via the Activation of the PIK3CA-AKT1-NFE2L2/BDNF Signaling Pathway.

Front Pharmacol. 2021-4-15

[3]
Association of Axillary Lymph Node Evaluation With Survival in Women Aged 70 Years or Older With Breast Cancer.

Front Oncol. 2021-1-28

[4]
Molecular Signature of Subtypes of Non-Small-Cell Lung Cancer by Large-Scale Transcriptional Profiling: Identification of Key Modules and Genes by Weighted Gene Co-Expression Network Analysis (WGCNA).

Cancers (Basel). 2019-12-21

[5]
Xiaoyao Pills Prevent Lipopolysaccharide-Induced Depression by Inhibiting Inflammation and Protecting Nerves.

Front Pharmacol. 2019-11-13

[6]
Exploring specific prognostic biomarkers in triple-negative breast cancer.

Cell Death Dis. 2019-10-24

[7]
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.

CA Cancer J Clin. 2018-9-12

[8]
Anti-endometriosis Mechanism of Based on Network Pharmacology.

Front Pharmacol. 2018-7-26

[9]
GeneMANIA update 2018.

Nucleic Acids Res. 2018-7-2

[10]
Paclitaxel and di-fluorinated curcumin loaded in albumin nanoparticles for targeted synergistic combination therapy of ovarian and cervical cancers.

Colloids Surf B Biointerfaces. 2018-3-28

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索