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原发性肛管直肠黑色素瘤：两例报告。

Primary anorectal melanoma: report of two cases.

作者信息

Lopez-Cutipa Ever Frank, Quintero-Aquino Lizbeth Katherine, Torres-Mattos Cesar

机构信息

Coloproctology Surgery, Guillermo Almenara National Hospital, Av. Grau 800, La Victoria, Lima, 15018, Peru.

Surgical Pathology and Necropsies, Guillermo Almenara National Hospital, Av. Grau 800, La Victoria, Lima, 15018, Peru.

出版信息

J Surg Case Rep. 2025 Jun 6;2025(6):rjaf376. doi: 10.1093/jscr/rjaf376. eCollection 2025 Jun.

DOI:10.1093/jscr/rjaf376
PMID:40486685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12140978/
Abstract

Anorectal melanoma is a rare and aggressive neoplasm with a poor prognosis; the overall survival rate at 5 years is around 20%. We report two clinical cases involving patients who experienced pain and bleeding associated with an anorectal mass. Histopathological studies confirmed the diagnosis of melanoma. The first case presented with localized disease characterized by a black, pedunculated lesion with irreducible prolapse managed with wide local excision. In the second case, the patient had a fixed, pink anal lesion accompanied by multiple inguinal and retroperitoneal lymphadenopathies. Due to the metastatic nature of the disease, immunotherapy was administered. Both patients remain alive after 1 year of follow-up.

摘要

肛管直肠黑色素瘤是一种罕见且侵袭性强的肿瘤，预后较差；5年总生存率约为20%。我们报告了两例临床病例，患者均出现与肛管直肠肿物相关的疼痛和出血症状。组织病理学研究确诊为黑色素瘤。第一例表现为局限性病变，特征为黑色带蒂肿物伴不可回纳性脱垂，采用广泛局部切除治疗。第二例患者有一个固定的粉红色肛门病变，并伴有多发腹股沟和腹膜后淋巴结病。由于疾病具有转移性，给予了免疫治疗。随访1年后，两名患者均存活。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3618/12140978/24922bcc9ff9/rjaf376f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3618/12140978/851cb40f30a3/rjaf376f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3618/12140978/62b1578b2140/rjaf376f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3618/12140978/fd1a57502584/rjaf376f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3618/12140978/9bef57f20fdb/rjaf376f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3618/12140978/8ed951950b12/rjaf376f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3618/12140978/104f59a2103e/rjaf376f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3618/12140978/24922bcc9ff9/rjaf376f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3618/12140978/851cb40f30a3/rjaf376f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3618/12140978/62b1578b2140/rjaf376f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3618/12140978/fd1a57502584/rjaf376f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3618/12140978/9bef57f20fdb/rjaf376f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3618/12140978/8ed951950b12/rjaf376f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3618/12140978/104f59a2103e/rjaf376f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3618/12140978/24922bcc9ff9/rjaf376f7.jpg

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本文引用的文献

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Survival Outcomes in Patients Undergoing Pelvic Exenteration for Pelvic Mucosal Melanomas: Retrospective Single Institution Australian Study.盆腔黏膜黑色素瘤患者行盆腔脏器切除术的生存结果：澳大利亚单机构回顾性研究
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Anorectal melanoma: systematic review of the current literature of an aggressive type of melanoma.直肠黑色素瘤：对一种侵袭性黑色素瘤的当前文献的系统回顾。
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Anorectal melanoma.
直肠黑色素瘤。
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Treatment and outcome trends and predictors of overall survival of rectal melanoma: Analysis of the National Cancer Database.直肠黑色素瘤的治疗和预后趋势及总生存预测因素：国家癌症数据库分析。
Eur J Surg Oncol. 2023 Jul;49(7):1275-1282. doi: 10.1016/j.ejso.2023.01.021. Epub 2023 Jan 25.
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Optimal surgical management strategy for treatment of primary anorectal malignant melanoma-a systematic review and meta-analysis.原发肛管直肠恶性黑色素瘤的最佳手术治疗策略：系统评价和荟萃分析。
Langenbecks Arch Surg. 2022 Dec;407(8):3193-3200. doi: 10.1007/s00423-022-02715-1. Epub 2022 Nov 4.
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Effect of surgical treatment for anorectal melanoma: a propensity score-matched analysis of the Surveillance, Epidemiology, and End Results programme data.肛门直肠黑色素瘤手术治疗效果的倾向评分匹配分析：监测、流行病学和最终结果计划数据。
BMJ Open. 2022 Apr 21;12(4):e053339. doi: 10.1136/bmjopen-2021-053339.
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Impact of adjuvant therapies following surgery for anal melanoma.手术治疗肛门黑色素瘤辅助治疗的影响。
Am J Surg. 2022 Jun;223(6):1132-1143. doi: 10.1016/j.amjsurg.2021.10.041. Epub 2021 Nov 11.
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Cancer Treat Res Commun. 2021;28:100415. doi: 10.1016/j.ctarc.2021.100415. Epub 2021 Jun 10.
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