Li Yuzheng, Yu Lili, Zhou Shiyao, Zhou Hua, Wu Qibiao
Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, and University Hospital, Macau University of Science and Technology, Macao, 999078, China.
Chinese Medicine Guangdong Laboratory (Hengqin Laboratory), Guangdong-Macao In-Depth Cooperation Zone in Hengqin, Zhuhai, 519000, China.
Oncol Res. 2025 May 29;33(6):1363-1376. doi: 10.32604/or.2025.059311. eCollection 2025.
Non-small cell lung cancer (NSCLC) involves complex alterations in the epidermal growth factor receptor (EGFR) signaling pathway. This study aims to integrate multimodal omics analyses to evaluate and enhance EGFR-targeted therapies.
We reviewed and synthesized omics data-including genomics, transcriptomics, proteomics, epigenomics, and metabolomics data-related to the EGFR pathway in NSCLC, examined the clinical outcomes of current therapies and proposed new treatment strategies.
Integrated omics analyses revealed the multifaceted role of EGFR in NSCLC. Transcriptomic analysis revealed gene expression alterations due to EGFR mutations, with upregulation of oncogenes and downregulation of tumor suppressors. Proteomics revealed complex interactions within the EGFR network, revealing cross-talk with other receptors. Epigenomics highlighted the impact of DNA methylation and histone modifications on EGFR and its downstream genes, whereas metabolomics demonstrated shifts in metabolic patterns essential for tumor growth.
This study highlights the critical role of multimodal omics in understanding the molecular landscape of NSCLC, offering insights into more effective, personalized therapies. Future advancements in omic technologies and analysis are expected to significantly enhance NSCLC diagnosis and treatment.
非小细胞肺癌（NSCLC）涉及表皮生长因子受体（EGFR）信号通路的复杂改变。本研究旨在整合多组学分析以评估和加强EGFR靶向治疗。
我们回顾并综合了与NSCLC中EGFR通路相关的组学数据，包括基因组学、转录组学、蛋白质组学、表观基因组学和代谢组学数据，研究了当前治疗的临床结果并提出了新的治疗策略。
综合组学分析揭示了EGFR在NSCLC中的多方面作用。转录组分析揭示了由于EGFR突变导致的基因表达改变，癌基因上调而肿瘤抑制基因下调。蛋白质组学揭示了EGFR网络内的复杂相互作用，显示了与其他受体的相互作用。表观基因组学突出了DNA甲基化和组蛋白修饰对EGFR及其下游基因的影响，而代谢组学证明了对肿瘤生长至关重要的代谢模式的转变。
本研究强调了多组学在理解NSCLC分子格局中的关键作用，为更有效、个性化的治疗提供了见解。预计组学技术和分析的未来进展将显著提高NSCLC的诊断和治疗水平。
