Tabassum Shehroze, Azhar Faraz, Shafiq Aimen, Ahsan Muneeba, Naeem Aroma, Naeem Farhan, Virk Hafeez Ul Hassan, Minhas Abdul Mannan Khan, Abramov Dmitry, Alraies M Chadi
Department of Internal Medicine, King Edward Medical University, Lahore, Pakistan.
Department of Internal Medicine, Allama Iqbal Medical College, Lahore, Pakistan.
Int J Cardiol Cardiovasc Risk Prev. 2025 May 8;26:200421. doi: 10.1016/j.ijcrp.2025.200421. eCollection 2025 Sep.
Sepsis and cardiovascular disease (CVD) are common conditions, and both contribute to mortality. The objective of our study is to explore the contemporary mortality trends associated with CVD and sepsis among patients ≥25 years in the United States (US).
We conducted an analysis of death data using CDC WONDER, extracting age-adjusted mortality rates (AAMR) per 100,000 for mortality with an underlying or contributing diagnosis of both CVD and sepsis. Trends by age, gender, ethnicity and race, census region, and metropolitan status were analyzed. Joinpoint regression calculated the annual percent change (APC) for AAMR with 95 % CI.
From 1999 to 2019, there were a total of 1,601,794 deaths related to CVD and sepsis. The AAMR related to both CVD and sepsis showed an overall decrease from 1999 to 2019 (1999: 37.9; 95 % CI: 37.6 to 38.1 vs. 2019: 35.4; 95 % CI: 35.2 to 35.7). Men had consistently higher AAMRs compared to women (Men: 41.5; 95 % CI: 41.4 to 41.6 vs. Women: 31.3; 95 % CI: 31.2 to 31.4). Non-Hispanic Black or African American individuals and adults aged ≥65 had the highest CVD and sepsis-related AAMRs. Similarly, the AAMRs were highest in the Northeastern region and among residents of metropolitan areas.
Though there has been a reduction in CVD and sepsis-related deaths among patients, significant disparities remain across various demographic groups, underscoring the need for continued research.
脓毒症和心血管疾病（CVD）是常见病症，二者都会导致死亡。我们研究的目的是探究美国25岁及以上患者中与CVD和脓毒症相关的当代死亡率趋势。
我们使用疾病控制与预防中心（CDC）的WONDER对死亡数据进行分析，提取每10万人中因CVD和脓毒症的潜在或促成诊断导致的年龄调整死亡率（AAMR）。分析了年龄、性别、种族和民族、人口普查区域以及大都市状况的趋势。连接点回归计算了AAMR的年度百分比变化（APC）及95%置信区间（CI）。
1999年至2019年，共有1601794例与CVD和脓毒症相关的死亡。1999年至2019年，与CVD和脓毒症相关的AAMR总体呈下降趋势（1999年：37.9；95%CI：37.6至38.1，对比2019年：35.4；95%CI：35.2至35.7）。男性的AAMR始终高于女性（男性：41.5；95%CI：41.4至41.6，对比女性：31.3；95%CI：31.2至31.4）。非西班牙裔黑人或非裔美国人以及65岁及以上成年人的CVD和脓毒症相关AAMR最高。同样，东北地区和大都市地区居民的AAMR最高。
尽管患者中与CVD和脓毒症相关的死亡有所减少，但不同人口群体之间仍存在显著差异，这突出了持续研究的必要性。
