Akhtar Muzamil, Farooqi Hanzala Ahmed, Nabi Rayyan, Abbasi Sabahat Ul Ain Munir, Picker Sarah MacKenzie, Ahmed Raheel
Gujranwala Medical College, Gujranwala, Pakistan.
Islamic International Medical College, Riphah International University, Islamabad, Pakistan.
Clin Cardiol. 2025 Jan;48(1):e70079. doi: 10.1002/clc.70079.
Parkinson disease (PD) and cardiovascular diseases (CVD) present significant health burdens, particularly among older adults. Patients with PD have an elevated risk of CVD-related mortality. Analyzing mortality trends in this population may help guide focused interventions.
Mortality data were extracted from the CDC WONDER database, using ICD-10 code G20 for PD and I00-I99 for CVD. Age-adjusted mortality rates (AAMR) per 100,000 were calculated and trends were examined across variables including gender, year, race, and urbanization, place of death, region, and state. Annual percentage change (APC) with 95% confidence intervals (CI) was computed using Joinpoint regression.
A total of 138 151 CVD-related deaths were reported among individuals with PD. The AAMR decreased from 23.5 in 1999 to 12.7 in 2020, with a notable decline between 1999 and 2014 (APC: -5.13; 95% CI, -5.44 to -4.86), followed by a modest increase from 2014 to 2020 (APC: 1.37; 95% CI, 0.16-3.05). Males exhibited higher AAMRs compared to females (Male AAMR: 22.6 vs. Female AAMR: 10.4). Non-Hispanic (NH) Whites had the highest AAMR (16.1), followed by Hispanics (11.2), NH Asians (10.2), and NH Blacks (9.7). Nonmetropolitan areas showed a higher AAMR (16.3) compared to metropolitan areas (14.9). State-level analysis indicated Nebraska with the highest AAMR (21.4), while Georgia recorded the lowest (9.9).
CVD-related mortality in PD patients has declined overall, though rates rose slightly from 2014 to 2020. Gender, racial, and geographic disparities highlight the need for targeted strategies to reduce cardiovascular risks in this population.
帕金森病（PD）和心血管疾病（CVD）带来了重大的健康负担，在老年人中尤为如此。帕金森病患者心血管疾病相关死亡率升高。分析该人群的死亡率趋势可能有助于指导针对性干预措施。
从美国疾病控制与预防中心（CDC）的WONDER数据库中提取死亡率数据，帕金森病使用国际疾病分类第十版（ICD - 10）编码G20，心血管疾病使用编码I00 - I99。计算每10万人的年龄调整死亡率（AAMR），并研究包括性别、年份、种族、城市化程度、死亡地点、地区和州等变量的趋势。使用Joinpoint回归计算95%置信区间（CI）的年度百分比变化（APC）。
帕金森病患者中总共报告了138,151例心血管疾病相关死亡。年龄调整死亡率从1999年的23.5降至2020年的12.7，在1999年至2014年间显著下降（APC：-5.13；95% CI，-5.44至-4.86），随后在2014年至2020年间略有上升（APC：1.37；95% CI，0.16 - 3.05）。男性的年龄调整死亡率高于女性（男性AAMR：22.6，女性AAMR：10.4）。非西班牙裔（NH）白人的年龄调整死亡率最高（16.1），其次是西班牙裔（11.2）、非西班牙裔亚洲人（10.2）和非西班牙裔黑人（9.7）。非都市地区的年龄调整死亡率（16.3）高于都市地区（14.9）。州级分析表明，内布拉斯加州的年龄调整死亡率最高（21.4），而佐治亚州最低（9.9）。
帕金森病患者心血管疾病相关死亡率总体呈下降趋势，尽管在2014年至2020年间有所上升。性别、种族和地理差异凸显了采取针对性策略降低该人群心血管风险的必要性。
