Géraud G, Andrieu P, Güell A, Tremoulet M, Bès A
Rev Neurol (Paris). 1985;141(5):371-8.
One hundred and eleven measurements of cerebral blood flow (C.B.F.) were performed using the Xenon 133 inhalation method in 80 cases of spontaneous subarachnoid hemorrhage of which 59 were due to ruptured aneurysms. This method is non-traumatic, reproducible and dependable. A correlation was found between clinical condition and C.B.F. values, but in a number of cases which cannot be dismissed, very low mean C.B.F. values or ischemic foci were revealed where clinical state gave no indication. A poor correlation appeared between vasospasm seen by angiography and ischemic foci detected by isotopic technique. Patients' age influenced C.B.F. values but not clinical evolution. No correlation was found between C.B.F. values and cisternal blood seen on CT scan. C.B.F. values, measured in the first two weeks of illness, were significantly higher in those patients having favorable outcome, whatever their clinical state at the time of C.B.F. measurement (comas excluded). The figure of 60 ml/100 g/min for mean cortical flow seemed to be a critical level below which the risk of complication was greater. Below this level or in cases or ischemic foci, surgery was delayed. Thus, C.B.F. measurement promises to be a valuable prognostic tool, playing an important role in the therapeutic strategy for this type of patients.
采用氙133吸入法对80例自发性蛛网膜下腔出血患者进行了111次脑血流量(C.B.F.)测量,其中59例由动脉瘤破裂引起。该方法无创、可重复且可靠。发现临床状况与C.B.F.值之间存在相关性,但在一些不能忽视的病例中,尽管临床状态无异常,却显示出极低的平均C.B.F.值或缺血灶。血管造影显示的血管痉挛与同位素技术检测到的缺血灶之间相关性较差。患者年龄影响C.B.F.值,但不影响临床病程。C.B.F.值与CT扫描所见脑池内血液之间未发现相关性。在发病的前两周进行测量时,无论测量C.B.F.时患者的临床状态如何(昏迷患者除外),预后良好的患者C.B.F.值显著更高。平均皮质血流量60毫升/100克/分钟似乎是一个临界值,低于该值并发症风险更高。低于此水平或存在缺血灶的病例,手术延迟进行。因此,C.B.F.测量有望成为一种有价值的预后工具,在这类患者的治疗策略中发挥重要作用。