1例2型自身免疫性胰腺炎提示两种潜在的疾病活动标志物

Natsui Kazuki, Yoshikawa Seiichi, Kagata Ayano, Horibata Yusuke, Usuda Hiroyuki, Takeuchi Manabu, Terai Shuji

Department of Gastroenterology, Nagaoka Red Cross Hospital, Nagaoka, Niigata, Japan.

Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

Gastro Hep Adv. 2025 Feb 1;4(6):100635. doi: 10.1016/j.gastha.2025.100635. eCollection 2025.

Autoimmune pancreatitis (AIP) is divided into 2 main subtypes: type 1 AIP (AIP-1) and type 2 AIP (AIP-2). This report describes a young woman diagnosed with AIP-2 using endoscopic ultrasound-guided tissue acquisition. AIP-2 has been reported less frequently than AIP-1 as serologic abnormalities and other organ involvement except for inflammatory bowel disease are absent. Additional laboratory analyses suggest that serum interleukin-8 and leucine-rich alpha-2 glycoprotein are more efficient disease activity biomarkers than conventional C-reactive proteins. We hope that this case report will contribute to the discovery of diagnostic biomarkers for AIP-2.

自身免疫性胰腺炎（AIP）主要分为2种亚型：1型AIP（AIP-1）和2型AIP（AIP-2）。本报告描述了一名通过内镜超声引导下组织获取诊断为AIP-2的年轻女性。由于除炎症性肠病外无血清学异常及其他器官受累情况，AIP-2的报道较AIP-1少。进一步的实验室分析表明，血清白细胞介素-8和富含亮氨酸的α-2糖蛋白比传统的C反应蛋白更有效地反映疾病活动的生物标志物。我们希望本病例报告将有助于发现AIP-2的诊断生物标志物。