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社区纳洛酮培训与分发项目的报告结果。

Reported outcomes from a community naloxone training and distribution program.

作者信息

Frederiks Kevin, Everett Maxwell, Powell Kristen Gilmore, Peterson N Andrew, Borys Suzanne, Hallcom Donald K, Cooperman Nina A

机构信息

Rutgers Robert Wood Johnson Medical School, 125 Paterson St., New Brunswick, NJ 08901, United States.

Rutgers University School of Social Work, 120 Albany St., New Brunswick, NJ 08901, United States.

出版信息

Drug Alcohol Depend Rep. 2025 May 6;15:100341. doi: 10.1016/j.dadr.2025.100341. eCollection 2025 Jun.

DOI:10.1016/j.dadr.2025.100341
PMID:40487295
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12140937/
Abstract

The United States opioid epidemic is an enormous public health crisis, claiming over 500,000 lives between 1999 and 2020. However, the increased availability of naloxone has saved many lives and led to the development of community-based naloxone training and distribution programs. We developed a naloxone education and distribution program in New Jersey in 2017. This program provides a 60-minute training for community members in various settings, such as police departments, community centers, etc. Participants were instructed to call the training and distribution program if they used their naloxone kit, and the program would replace it. Callers were asked a short survey about behaviors during the naloxone administration and overdose outcome. From January 2018 through June 2022, 191 calls to report an overdose and request a new kit were received. Overall, 70 (37 %) of the reported naloxone administrations were by police, 38 (20 %) family/friends, and 50 (26 %) strangers. The most common actions taken during the overdose included: 162 (85 %) calling EMS; 161 (84 %) staying with the person who overdosed until EMS arrived; and 131 (69 %) checking the individual who overdosed for signs of breathing. Individuals who helped with an overdose were able to revive the person in 172 (90 %) of the reported overdoses. Our data suggests that participants in these programs will use naloxone for opioid overdoses whether the victim is known to the participant or a stranger. Future research should focus on understanding outcomes of and behaviors during overdose episodes that are not reported to the program.

摘要

美国的阿片类药物泛滥是一场巨大的公共卫生危机,在1999年至2020年间导致超过50万人死亡。然而,纳洛酮可用性的提高挽救了许多生命,并促使基于社区的纳洛酮培训和分发项目得以发展。我们于2017年在新泽西州开展了一项纳洛酮教育和分发项目。该项目为警察部门、社区中心等各种场所的社区成员提供60分钟的培训。如果参与者使用了纳洛酮试剂盒,他们会被指导致电培训和分发项目,该项目会更换试剂盒。致电者会被问及一份关于纳洛酮给药期间行为和过量用药结果的简短调查问卷。从2018年1月到2022年6月,共接到191个报告过量用药并请求提供新试剂盒的电话。总体而言,报告的纳洛酮给药中,70次(37%)是由警察进行的,38次(20%)是由家人/朋友进行的,50次(26%)是由陌生人进行的。过量用药期间最常见的行为包括:162次(85%)呼叫急救医疗服务(EMS);161次(84%)陪伴过量用药者直到EMS到达;131次(69%)检查过量用药者是否有呼吸迹象。在报告的过量用药事件中,172次(90%)中帮助他人过量用药的人能够使患者苏醒。我们的数据表明,这些项目的参与者会在阿片类药物过量用药时使用纳洛酮,无论受害者是参与者认识的人还是陌生人。未来的研究应侧重于了解未向该项目报告的过量用药事件的结果和行为。

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本文引用的文献

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Effectiveness of naloxone distribution in community settings to reduce opioid overdose deaths among people who use drugs: a systematic review and meta-analysis.社区环境中纳洛酮分发在减少吸毒者阿片类药物过量死亡方面的有效性:一项系统评价和荟萃分析。
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National and regional trends in fentanyl seizures in the United States, 2017-2023.2017 - 2023年美国芬太尼缉获量的国家和地区趋势
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Statewide efforts to address the opioid epidemic: Results from a national survey of single state agencies.全州范围内解决阿片类药物泛滥问题的努力:全国单一州机构调查的结果。
J Subst Use Addict Treat. 2024 May;160:209309. doi: 10.1016/j.josat.2024.209309. Epub 2024 Feb 8.
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Naloxone administration by nonmedical providers- a descriptive study of County sheriff department training.非医疗人员使用纳洛酮——县治安部门培训的描述性研究。
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6
Association of Take-Home Naloxone and Opioid Overdose Reversals Performed by Patients in an Opioid Treatment Program.门诊纳洛酮与阿片类药物过量逆转患者在阿片类药物治疗项目中的相关性。
JAMA Netw Open. 2020 Feb 5;3(2):e200117. doi: 10.1001/jamanetworkopen.2020.0117.
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Naloxone Dosing After Opioid Overdose in the Era of Illicitly Manufactured Fentanyl.在非法制造的芬太尼时代,阿片类药物过量后纳洛酮的给药剂量。
J Med Toxicol. 2020 Jan;16(1):41-48. doi: 10.1007/s13181-019-00735-w. Epub 2019 Aug 30.
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Intranasal naloxone rapidly occupies brain mu-opioid receptors in human subjects.纳洛酮经鼻给药能迅速占据人体脑内μ-阿片受体。
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