Fewell J E, Williams B J, Hill D E
Sleep. 1985;8(3):254-60. doi: 10.1093/sleep/8.3.254.
We investigated the effect of sleep on blood pressure control in seven lambs aged 10-14 days. Each lamb had previously been anesthetized and instrumented for measurements of electrocorticogram, electron-oculogram, nuchal and diaphragm electromyograms, pulmonary blood flow (electromagnetic flow transducer), and aortic and pulmonic blood pressure. The lambs were allowed to recover from surgery at least 3 days before they were studied. Measurements were made at the highest and lowest mean aortic pressure during quiet wakefulness, quiet sleep, and active sleep. The lowest values of mean aortic pressure progressively decreased as the animals went from quiet wakefulness to quiet sleep to active sleep. Mean aortic pressure was most variable during active sleep. During active sleep, transient hypertensive episodes were superimposed upon a tonic hypotensive phase. During the transient hypertensive episodes in active sleep, changes in mean aortic pressure were primarily caused by an increase in systemic vascular resistance rather than by changes in cardiac output. Heart rate was always lower during active sleep than during quiet wakefulness or quiet sleep. These results provide evidence that sleep state has a marked influence on blood pressure control in lambs.
我们研究了睡眠对7只10 - 14日龄羔羊血压控制的影响。每只羔羊此前都已接受麻醉并安装了仪器，用于测量脑电图、眼电图、颈部和膈肌肌电图、肺血流量（电磁流量传感器）以及主动脉和肺动脉血压。在进行研究前，让羔羊从手术中恢复至少3天。在安静觉醒、安静睡眠和主动睡眠期间，于主动脉平均压最高值和最低值时进行测量。随着动物从安静觉醒进入安静睡眠再到主动睡眠，主动脉平均压的最低值逐渐降低。主动睡眠期间，主动脉平均压变化最大。在主动睡眠期间，短暂的高血压发作叠加在持续性低血压阶段之上。在主动睡眠期间的短暂高血压发作期间，主动脉平均压的变化主要是由全身血管阻力增加引起的，而非心输出量的变化。主动睡眠期间的心率始终低于安静觉醒或安静睡眠期间。这些结果证明睡眠状态对羔羊的血压控制有显著影响。
