Romanò Anna, Pagiatakis Christina, Gornati Rosalba, Bernardini Giovanni, Papait Roberto
Department of Biotechnologies and Life Science, University of Insubria, Varese, Italy.
Department of Cardiovascular Medicine, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
iScience. 2025 May 8;28(6):112613. doi: 10.1016/j.isci.2025.112613. eCollection 2025 Jun 20.
Epigenetics is a complex network of molecular mechanisms, including DNA modifications, histone modifications, and non-coding RNA transcripts that influence gene transcription in heritable ways across cells. Over the last decades, epigenetic mechanisms have gained significant attention in the field of toxicology. Various research groups are investigating the epigenetic impact of toxicants due to their role in mediating the effects of environmental factors on cellular function, in complex diseases, and in explaining adverse effects on offspring. Here, we give an overview of these studies, exploring the intersection of epigenetics and toxicology and focusing on how not only environmental pollutants but also recreational substances, such as tobacco smoke and alcoholic beverages, can impact DNA and histone modifications.
表观遗传学是一个复杂的分子机制网络，包括DNA修饰、组蛋白修饰和非编码RNA转录本，它们以可遗传的方式影响细胞间的基因转录。在过去几十年中，表观遗传机制在毒理学领域受到了广泛关注。由于其在介导环境因素对细胞功能的影响、复杂疾病以及解释对后代的不良影响方面的作用，各个研究小组正在研究毒物的表观遗传影响。在此，我们对这些研究进行概述，探讨表观遗传学与毒理学的交叉点，并重点关注不仅环境污染物，还有烟草烟雾和酒精饮料等消遣性物质如何影响DNA和组蛋白修饰。
