Jung J-K, Quelapio M, Cho S N
International Tuberculosis Research Center, 236 Gaposunhwan-ro, Masanhappo-gu, Changwon-si, Gyeongsangnam-do, Republic of Korea.
KNCV TB Foundation, Postbus 146, 2501 CC Den Haag, The Hague, The Netherlands.
Public Health Action. 2025 Jun 4;15(2):88-90. doi: 10.5588/pha.25.0009. eCollection 2025 Jun.
As part of the LIFT-TB project, we investigated the efficacy and safety of the BPaL regimen, while enhancing laboratory diagnostic capacity for drug-resistant-TB. Challenges include sample contamination, excessive workload, test kit shortages, unreliable results and systemic issues such as infrastructure, delayed procurement, workforce constraints and reliance on paper-based data reporting. Our study highlights the need for a system-level approach backed by strong national leadership to strengthen TB diagnostic capacity. Although countries must take ownership of laboratory system improvements, a harmonized and coordinated approach among international stakeholders is essential in specialized areas, such as external quality assurance, capacity building, and introducing innovative diagnostic technologies.
作为“提高结核病治疗成功率”（LIFT-TB）项目的一部分，我们研究了BPaL方案的疗效和安全性，同时提高了耐多药结核病的实验室诊断能力。挑战包括样本污染、工作量过大、检测试剂盒短缺、结果不可靠以及基础设施、采购延迟、人员限制和依赖纸质数据报告等系统性问题。我们的研究强调，需要在强有力的国家领导支持下采取系统层面的方法来加强结核病诊断能力。尽管各国必须自主改进实验室系统，但在外部质量保证、能力建设和引入创新诊断技术等专业领域，国际利益相关者之间协调一致的方法至关重要。
