小细胞肺癌所致γ-氨基丁酸B受体抗体相关边缘叶脑炎：两例报告
Gamma-aminobutiric acid-B receptor antibody-related limbic encephalitis due to small cell lung carcinoma: Two case reports.
作者信息
Myrou Athena D, Spilioti Martha G, Tsolaki Anthoula C, Frontistis Antonis N, Savopoulos Christos G
机构信息
Department of Internal Medicine, AHEPA University General Hospital, Thessaloniki 54636, Greece.
Department of Neurology, AHEPA University General Hospital, Thessaloniki 54636, Greece.
出版信息
World J Clin Cases. 2025 Jun 6;13(16):97716. doi: 10.12998/wjcc.v13.i16.97716.
BACKGROUND
Paraneoplastic limbic encephalitis (LE) is an inflammatory condition that affects the limbic system, cerebellum, and peripheral nervous system. It causes a range of symptoms including short-term memory loss, impaired cognitive function, behavioral and psychological disorders, and seizures. Paraneoplastic LE can occur when an immune response is activated due to antibodies targeting gamma-aminobutyric acid (GABA) B receptor (GABABR) interacting with antigens on tumor cells and the nervous system, resulting in tumors primarily as small cell lung carcinoma (SCLC).
CASE SUMMARY
We discuss two cases of GABABR antibody-related LE resulting from SCLC. The patients' symptoms were managed with immunotherapy but ended in premature death due to chemotherapy-related complications.
CONCLUSION
Paraneoplastic syndrome is a notable cause of LE. Early intravenous immunoglobulin therapy may lead to temporary remission.
背景
副肿瘤性边缘叶脑炎（LE）是一种影响边缘系统、小脑和周围神经系统的炎症性疾病。它会引发一系列症状，包括短期记忆丧失、认知功能受损、行为和心理障碍以及癫痫发作。当针对γ-氨基丁酸（GABA）B受体（GABABR）的抗体与肿瘤细胞和神经系统上的抗原相互作用激活免疫反应时，就会发生副肿瘤性LE，主要导致肿瘤为小细胞肺癌（SCLC）。
病例总结
我们讨论了两例由SCLC引起的GABABR抗体相关LE病例。患者的症状通过免疫疗法进行管理，但由于化疗相关并发症最终过早死亡。
结论
副肿瘤综合征是LE的一个显著病因。早期静脉注射免疫球蛋白治疗可能会导致暂时缓解。
Zotero 插件